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Science 18 June 1982:
Vol. 216. no. 4552, pp. 1341 - 1343
DOI: 10.1126/science.7079771
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Articles

Science, Vol 216, Issue 4552, 1341-1343
Copyright © 1982 by American Association for the Advancement of Science

articles

Activity-dependent K+ accumulation in the developing rat optic nerve

BW Connors, BR Ransom, DM Kunis, and MJ Gutnick

Potassium-sensitive microelectrodes were used to study activity-dependent changes of extracellular potassium ion concentration ([K+]o) in rat optic nerves of different postnatal ages (1 day to adulthood). The maximum level to which [K+]o rose with optimal frequencies of stimulation depended on age: mean maximum evoked [K+]o was 17.2 microM in 1- to 3-day-old optic nerves and 9.8 microM in adult nerves. The ceiling [K+]o seen in immature optic nerves, which is uniquely large for a mammalian central nervous system structure, may result from a relatively enhanced rate of evoked K+ release.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Genetic and Physiological Evidence That Oligodendrocyte Gap Junctions Contribute to Spatial Buffering of Potassium Released during Neuronal Activity.
D. M. Menichella, M. Majdan, R. Awatramani, D. A. Goodenough, E. Sirkowski, S. S. Scherer, and D. L. Paul (2006)
J. Neurosci. 26, 10984-10991
   Abstract »    Full Text »    PDF »
Glycogen regulation and functional role in mouse white matter.
A. M Brown, S. B. Tekkok, and B. R Ransom (2003)
J. Physiol. 549, 501-512
   Abstract »    Full Text »    PDF »
Computer Model for Action Potential Propagation Through Branch Point in Myelinated Nerves.
L. Zhou and S. Y. Chiu (2001)
J Neurophysiol 85, 197-210
   Abstract »    Full Text »    PDF »
Activity-dependent extracellular K+ accumulation in rat optic nerve: the role of glial and axonal Na+ pumps.
C. B Ransom, B. R Ransom, and H. Sontheimer (2000)
J. Physiol. 522, 427-442
   Abstract »    Full Text »    PDF »
Chemotopic, Combinatorial, and Noncombinatorial Odorant Representations in the Olfactory Bulb Revealed Using a Voltage-Sensitive Axon Tracer.
R. W. Friedrich and S. I. Korsching (1998)
J. Neurosci. 18, 9977-9988
   Abstract »    Full Text »    PDF »
Aquaporin-4 Water Channel Protein in the Rat Retina and Optic Nerve: Polarized Expression in Muller Cells and Fibrous Astrocytes.
E. A. Nagelhus, M. L. Veruki, R. Torp, F.-M. Haug, J. H. Laake, S. Nielsen, P. Agre, and O. P. Ottersen (1998)
J. Neurosci. 18, 2506-2519
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)