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Science 18 June 1982:
Vol. 216. no. 4552, pp. 1337 - 1339
DOI: 10.1126/science.7079769
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Articles

Science, Vol 216, Issue 4552, 1337-1339
Copyright © 1982 by American Association for the Advancement of Science

articles

Tritiated imipramine binding sites are decreased in the frontal cortex of suicides

M Stanley, J Virgilio, and S Gershon

Binding characteristics of tritiated imipramine were determined in the frontal cortex of suicides and well-matched controls. Maximal binding was significantly lower in brains from the suicides. This finding is consistent with reports of decreased tritiated imipramine binding in the platelets of patients diagnosed as having a major affective disorder.


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Pharmacological Characterization of N,N-Dimethyl-2-(2-amino-4-methylphenyl thio)benzylamine as a Ligand of the Serotonin Transporter with High Affinity and Selectivity.
S. Chalon, J. Tarkiainen, L. Garreau, H. Hall, P. Emond, J. Vercouillie, L. Farde, P. Dasse, K. Varnas, J.-C. Besnard, et al. (2003)
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A Serotonin Transporter Gene Promoter Polymorphism (5-HTTLPR) and Prefrontal Cortical Binding in Major Depression and Suicide.
J. J. Mann, Y.-y. Huang, M. D. Underwood, S. A. Kassir, S. Oppenheim, T. M. Kelly, A. J. Dwork, and V. Arango (2000)
Arch Gen Psychiatry 57, 729-738
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Phosphorylation and Sequestration of Serotonin Transporters Differentially Modulated by Psychostimulants.
S. Ramamoorthy and R. D. Blakely (1999)
Science 285, 763-766
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Impulsive Aggression in Personality Disorder Correlates With Tritiated Paroxetine Binding in the Platelet.
E. F. Coccaro, R. J. Kavoussi, Y. I. Sheline, J. D. Lish, and J. G. Csernansky (1996)
Arch Gen Psychiatry 53, 531-536
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Selective Abnormalities of Prefrontal Serotonergic Receptors in Schizophrenia: A Postmortem Study.
M. Laruelle, A. Abi-Dargham, M. F. Casanova, R. Toti, D. R. Weinberger, and J. E. Kleinman (1993)
Arch Gen Psychiatry 50, 810-818
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Unaltered number of brain serotonin uptake sites in suicide victims.
A. Andersson, A. Eriksson, and J. Marcusson (1992)
J Psychopharmacol 6, 509-513
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The Emergence of Suicidal Ideation and Behavior During Antidepressant Pharmacotherapy.
J. J. Mann and S. Kapur (1991)
Arch Gen Psychiatry 48, 1027-1033
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Tritiated Imipramine Binding: A Peripheral Marker for Serotonin in Parkinson's Disease.
M. Sano, M. Stanley, A. Lawton, L. Cote, J. Williams, Y. Stern, K. Marder, and R. Mayeux (1991)
Arch Neurol 48, 1052-1054
   Abstract »    PDF »
Elevated Plasma Concentrations of {alpha}1-Acid Glycoprotein, a Putative Endogenous Inhibitor of the Tritiated Imipramine Binding Site, in Depressed Patients.
C. B. Nemeroff, K. R. R. Krishnan, D. G. Blazer, D. L. Knight, D. Benjamin, and L. R. Meyerson (1990)
Arch Gen Psychiatry 47, 337-340
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Serotonergic Studies in Patients With Affective and Personality Disorders: Correlates With Suicidal and Impulsive Aggressive Behavior.
E. F. Coccaro, L. J. Siever, H. M. Klar, G. Maurer, K. Cochrane, T. B. Cooper, R. C. Mohs, and K. L. Davis (1989)
Arch Gen Psychiatry 46, 587-599
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Autoradiographic Analysis of Tritiated Imipramine Binding in the Human Brain Post Mortem: Effects of Suicide.
R. Gross-Isseroff, M. Israeli, and A. Biegon (1989)
Arch Gen Psychiatry 46, 237-241
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Reduced Corticotropin Releasing Factor Binding Sites in the Frontal Cortex of Suicide Victims.
C. B. Nemeroff, M. J. Owens, G. Bissette, A. C. Andorn, and M. Stanley (1988)
Arch Gen Psychiatry 45, 577-579
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Neuroendocrine Responses to Intravenous Tryptophan in Major Depression.
P. J. Cowen and E. M. Charig (1987)
Arch Gen Psychiatry 44, 958-966
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Effects of Antidepressant Treatments on Platelet Tritiated Imipramine Binding in Major Depressive Disorder.
A. Wagner, A. Aberg-Wistedt, M. Asberg, L. Bertilsson, B. Martensson, and D. Montero (1987)
Arch Gen Psychiatry 44, 870-877
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Cerebrospinal Fluid Monoamine Metabolite Levels in Male Arsonists.
M. Virkkunen, A. Nuutila, F. K. Goodwin, and M. Linnoila (1987)
Arch Gen Psychiatry 44, 241-247
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Electroconvulsive Shock Therapy and Maximum Binding of Platelet Tritiated Imipramine Binding in Depression.
S. Z. Langer, D. Sechter, H. Loo, R. Raisman, and E. Zarifian (1986)
Arch Gen Psychiatry 43, 949-952
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Increased Serotonin2 and {beta}-Adrenergic Receptor Binding in the Frontal Cortices of Suicide Victims.
J. J. Mann, M. Stanley, P. A. McBride, and B. S. McEwen (1986)
Arch Gen Psychiatry 43, 954-959
   Abstract »    PDF »
Serotonin and 5-Hydroxyindoleacetic Acid in Brains of Suicide Victims: Comparison in Chronic Schizophrenic Patients With Suicide as Cause of Death.
E. R. Korpi, J. E. Kleinman, S. I. Goodman, I. Phillips, L. E. DeLisi, M. Linnoila, and R. J. Wyatt (1986)
Arch Gen Psychiatry 43, 594-600
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A strong influence of serotonin axons on beta-adrenergic receptors in rat brain.
C. Stockmeier, A. Martino, and K. Kellar (1985)
Science 230, 323-325
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Cerebral Metabolic Rates for Glucose in Mood Disorders: Studies With Positron Emission Tomography and Fluorodeoxyglucose F 18.
L. R. Baxter Jr, M. E. Phelps, J. C. Mazziotta, J. M. Schwartz, R. H. Gerner, C. E. Selin, and R. M. Sumida (1985)
Arch Gen Psychiatry 42, 441-447
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Effect of 5-Hydroxytryptophan on Serum Cortisol Levels in Major Affective Disorders: I. Enhanced Response in Depression and Mania.
H. Y. Meltzer, B. Umberkoman-Wiita, A. Robertson, B. Jo Tricou, M. Lowy, and R. Perline (1984)
Arch Gen Psychiatry 41, 366-374
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Serotonergic Function in Depression: Prolactin Response to Intravenous Tryptophan in Depressed Patients and Healthy Subjects.
G. R. Heninger, D. S. Charney, and D. E. Sternberg (1984)
Arch Gen Psychiatry 41, 398-402
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