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Science 18 June 1982:
Vol. 216. no. 4552, pp. 1331 - 1334
DOI: 10.1126/science.7079767
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Articles

Science, Vol 216, Issue 4552, 1331-1334
Copyright © 1982 by American Association for the Advancement of Science

articles

Noise-induced hearing loss can alter neural coding and increase excitability in the central nervous system

JF Willott and SM Lu

Responses of auditory neurons in the inferior colliculi of mice were studied longitudinally before and shortly after each animal was exposed to intense noise. Noise exposure caused expected losses in auditory sensitivity, but in 31 percent of the neurons studied, unexpected alterations of temporal patterns of action potentials were observed: certain suprathreshold stimuli that had evoked only transient "onset" responses or inhibition of spontaneous discharges prior to noise exposure came to elicit sustained excitation after exposure. Thus, noise-induced hearing loss can be associated with increases in neural responsivity and alterations of normal neural coding processes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Inhibitory neurotransmission, plasticity and aging in the mammalian central auditory system.
D. M. Caspary, L. Ling, J. G. Turner, and L. F. Hughes (2008)
J. Exp. Biol. 211, 1781-1791
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