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Science 18 June 1982: Vol. 216. no. 4552, pp. 1317 - 1319 DOI: 10.1126/science.7043737
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Articles
Science, Vol 216, Issue 4552, 1317-1319
Copyright © 1982 by American Association for the Advancement of Science
Lyme disease-a tick-borne spirochetosis?
W Burgdorfer,
AG Barbour,
SF Hayes,
JL Benach,
E Grunwaldt,
and
JP Davis
A treponema-like spirochete was detected in and isolated from adult Ixodes dammini, the incriminated tick vector of Lyme disease. Causally related to the spirochetes may be long-lasting cutaneous lesions that appeared on New Zealand White rabbits 10 to 12 weeks after infected ticks fed on them. Samples of serum from patients with Lyme disease were shown by indirect immunofluorescence to contain antibodies to this agent. It is suggested that the newly discovered spirochete is involved in the etiology of Lyme disease.
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- Infection and Inflammation in Skeletal Muscle from Nonhuman Primates Infected with Different Genospecies of the Lyme Disease Spirochete Borrelia burgdorferi.
- D. Cadavid, Y. Bai, D. Dail, M. Hurd, K. Narayan, E. Hodzic, S. W. Barthold, and A. R. Pachner (2003)
Infect. Immun.
71, 7087-7098
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- Acylated Cholesteryl Galactoside as a Novel Immunogenic Motif in Borrelia burgdorferi Sensu Stricto.
- N. W. J. Schroder, U. Schombel, H. Heine, U. B. Gobel, U. Zahringer, and R. R. Schumann (2003)
J. Biol. Chem.
278, 33645-33653
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- First isolation and characterization of Borrelia burgdorferi sensu lato strains from Ixodes ricinus ticks in Turkey.
- E. S. Guner, N. Hashimoto, N. Takada, K. Kaneda, Y. Imai, and T. Masuzawa (2003)
J. Med. Microbiol.
52, 807-813
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- The Absence of Linear Plasmid 25 or 28-1 of Borrelia burgdorferi Dramatically Alters the Kinetics of Experimental Infection via Distinct Mechanisms.
- M. Labandeira-Rey, J. Seshu, and J. T. Skare (2003)
Infect. Immun.
71, 4608-4613
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- PCR-Reverse Line Blot Typing Method Underscores the Genomic Heterogeneity of Borrelia valaisiana Species and Suggests Its Potential Involvement in Lyme Disease.
- E. Godfroid, C. Min Hu, P.-F. Humair, A. Bollen, and L. Gern (2003)
J. Clin. Microbiol.
41, 3690-3698
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- Tripalmitoyl-S-Glyceryl-Cysteine-Dependent OspA Vaccination of Toll-Like Receptor 2-Deficient Mice Results in Effective Protection from Borrelia burgdorferi Challenge.
- A. Yoder, X. Wang, Y. Ma, M. T. Philipp, M. Heilbrun, J. H. Weis, C. J. Kirschning, R. M. Wooten, and J. J. Weis (2003)
Infect. Immun.
71, 3894-3900
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- A newly discovered cholesteryl galactoside from Borrelia burgdorferi.
- G. Ben-Menachem, J. Kubler-Kielb, B. Coxon, A. Yergey, and R. Schneerson (2003)
PNAS
100, 7913-7918
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- Study and treatment of post Lyme disease (STOP-LD): A randomized double masked clinical trial.
- L. B. Krupp, L. G. Hyman, R. Grimson, P. K. Coyle, P. Melville, S. Ahnn, R. Dattwyler, and B. Chandler (2003)
Neurology
60, 1923-1930
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- Plasmid Stability during In Vitro Propagation of Borrelia burgdorferi Assessed at a Clonal Level.
- D. Grimm, A. F. Elias, K. Tilly, and P. A. Rosa (2003)
Infect. Immun.
71, 3138-3145
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- The Immune Response at Onset and During Recovery From Borrelia burgdorferi Meningoradiculitis.
- S. Cepok, D. Zhou, F. Vogel, B. Rosche, V. Grummel, N. Sommer, and B. Hemmer (2003)
Arch Neurol
60, 849-855
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- Conservation of Plasmid Maintenance Functions between Linear and Circular Plasmids in Borrelia burgdorferi.
- P. E. Stewart, G. Chaconas, and P. Rosa (2003)
J. Bacteriol.
185, 3202-3209
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- Immunological and genetic characterization of Borrelia burgdorferi BapA and EppA proteins.
- J. C. Miller and B. Stevenson (2003)
Microbiology
149, 1113-1125
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- Molecular Characterization of Anaplasma phagocytophilum and Borrelia burgdorferi in Ixodes scapularis Ticks from Pennsylvania.
- J. W. Courtney, R. L. Dryden, J. Montgomery, B. S. Schneider, G. Smith, and R. F. Massung (2003)
J. Clin. Microbiol.
41, 1569-1573
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- In Vitro Susceptibility Testing of Four Antibiotics against Borrelia burgdorferi: a Comparison of Results for the Three Genospecies Borrelia afzelii, Borrelia garinii, and Borrelia burgdorferi Sensu Stricto.
- M. Sicklinger, R. Wienecke, and U. Neubert (2003)
J. Clin. Microbiol.
41, 1791-1793
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- Regulation of Expression of the Borrelia burgdorferi {beta}3-Chain Integrin Ligand, P66, in Ticks and in Culture.
- C. Cugini, M. Medrano, T. G. Schwan, and J. Coburn (2003)
Infect. Immun.
71, 1001-1007
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- Expression of spoT in Borrelia burgdorferi during Serum Starvation.
- M. B. Concepcion and D. R. Nelson (2003)
J. Bacteriol.
185, 444-452
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- Genetic Variability within Borrelia burgdorferi Sensu Lato Genospecies Established by PCR-Single-Strand Conformation Polymorphism Analysis of the rrfA-rrlB Intergenic Spacer in Ixodes ricinus Ticks from the Czech Republic.
- M. Derdakova, L. Beati, B. Pet'ko, M. Stanko, and D. Fish (2003)
Appl. Envir. Microbiol.
69, 509-516
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- Elimination of Channel-Forming Activity by Insertional Inactivation of the p13 Gene in Borrelia burgdorferi.
- Y. Ostberg, M. Pinne, R. Benz, P. Rosa, and S. Bergstrom (2002)
J. Bacteriol.
184, 6811-6819
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- Morphoea and Borrelia burgdorferi: results from the Scottish Highlands in the context of the world literature.
- J R Goodlad, M M Davidson, P Gordon, R Billington, and D O Ho-Yen (2002)
Mol. Pathol.
55, 374-378
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- groEL Expression in gyrB Mutants of Borrelia burgdorferi.
- J. Alverson and D. S. Samuels (2002)
J. Bacteriol.
184, 6069-6072
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- OspE-Related, OspF-Related, and Elp Lipoproteins Are Immunogenic in Baboons Experimentally Infected with Borrelia burgdorferi and in Human Lyme Disease Patients.
- P. S. Hefty, C. S. Brooks, A. M. Jett, G. L. White, S. K. Wikel, R. C. Kennedy, and D. R. Akins (2002)
J. Clin. Microbiol.
40, 4256-4265
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- Complement Inhibitor Factor H Binding to Lyme Disease Spirochetes Is Mediated by Inducible Expression of Multiple Plasmid-Encoded Outer Surface Protein E Paralogs.
- A. Alitalo, T. Meri, H. Lankinen, I. Seppala, P. Lahdenne, P. S. Hefty, D. Akins, and S. Meri (2002)
J. Immunol.
169, 3847-3853
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