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Science 11 June 1982:
Vol. 216. no. 4551, pp. 1237 - 1239
DOI: 10.1126/science.7079756
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Articles

Science, Vol 216, Issue 4551, 1237-1239
Copyright © 1982 by American Association for the Advancement of Science

articles

Growth hormone stimulates longitudinal bone growth directly

OG Isaksson, JO Jansson, and IA Gause

Local administration of human growth hormone in vivo to the cartilage growth plate of the proximal tibia of hypophysectomized rats resulted in accelerated longitudinal bone growth. This finding suggests that growth hormone directly stimulates the cells in the growth plate, and does not support the theory that the increase in the plasma concentration of somatomedin that follows growth hormone administration is the cause of this stimulation.


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