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ArticlesCopyright © 1982 by American Association for the Advancement of Science
Tumorigenesis at a predetermined oral site after one intraperitoneal injection of N-nitroso-N-methylurea
Tumors in the soft tissues of the oral cavity of rats developed at predetermined sites as a result of a combination of an intraperitoneal injection of a direct-acting carcinogen. N-nitro-N-methylurea, and a continuous irritation of the buccal mucosa by a stainless steel wire. The incidence of histologically malignant tumors was significantly higher in the irritated area than in any other area of the body. These results constitute evidence for a carcinogenic mechanism whereby the cells that develop into tumors may require the promotional effect of a nonspecific, nonmutagenic stimulus.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)
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