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Science 11 June 1982:
Vol. 216. no. 4551, pp. 1230 - 1233
DOI: 10.1126/science.7043736
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Articles

Science, Vol 216, Issue 4551, 1230-1233
Copyright © 1982 by American Association for the Advancement of Science

articles

Induction of crisis forms in cultured Plasmodium falciparum with human immune serum from Sudan

JB Jensen, MT Boland, and M Akood

Serums from 90 individuals from three areas in Sudan were tested for inhibitory activity against cultures of Plasmodium falciparum. In addition to inhibitory activity against merozoite invasion, all of the serums demonstrated, in varying degrees, the ability to retard intraerythrocyte development, leading to crisis forms and parasite deterioration. These retardation factors could be removed by absorption of immune serum with parasite-infected erythrocytes and were demonstrable in purified immunoglobulin fractions. Serum from donors in hypoendemic Khartoum did not retard parasite development.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
HIGH TITERS OF IgG ANTIBODIES AGAINST PLASMODIUM FALCIPARUM SERINE REPEAT ANTIGEN 5 (SERA5) ARE ASSOCIATED WITH PROTECTION AGAINST SEVERE MALARIA IN UGANDAN CHILDREN.
B. OKECH, G. MUJUZI, A. OGWAL, H. SHIRAI, T. HORII, and T. G. EGWANG (2006)
Am J Trop Med Hyg 74, 191-197
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