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Science 4 June 1982:
Vol. 216. no. 4550, pp. 1133 - 1134
DOI: 10.1126/science.6210958
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Articles

Science, Vol 216, Issue 4550, 1133-1134
Copyright © 1982 by American Association for the Advancement of Science

articles

Suppressor T lymphocytes control the development of primary skin cancers in ultraviolet-irradiated mice

MS Fisher and ML Kripke

Exposure of mice to ultraviolet radiation results in the development of suppressor T lymphocytes in lymphoid organs, followed by the appearance of primary skin cancers. The presence or absence of these suppressor lymphocytes determines whether or not primary cancers will develop in the ultraviolet-irradiated skin. This demonstrates the importance of immunological regulatory pathways in carcinogenesis and provides an example of immunological surveillance.


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IL-10 Controls Ultraviolet-Induced Carcinogenesis in Mice.
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Cis-urocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT2A receptor.
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How Can We Best Directly Show that Immunity Influenced by Diet Modifies Cancer: Studies with Dietary Fat in a UV-Carcinogenesis Model.
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Ultraviolet Irradiation Suppresses T Cell Activation via Blocking TCR-Mediated ERK and NF-{kappa}B Signaling Pathways.
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An Important Role of CD80/CD86-CTLA-4 Signaling during Photocarcinogenesis in Mice.
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Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition.
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Fas Ligand: A Sensor for DNA Damage Critical in Skin Cancer Etiology.
L. L. Hill, A. Ouhtit, S. M. Loughlin, M. L. Kripke, H. N. Ananthaswamy, and L. B. Owen-Schaub (1999)
Science 285, 898-900
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A Critical Role for Fas Ligand in the Active Suppression of Systemic Immune Responses by Ultraviolet Radiation.
L. L. Hill, V. K. Shreedhar, M. L. Kripke, and L. B. Owen-Schaub (1999)
J. Exp. Med. 189, 1285-1294
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Urocanic Acid Enhances IL-10 Production in Activated CD4+ T Cells.
V. Holan, L. Kuffova, A. Zajicova, M. Krulova, M. Filipec, P. Holler, and A. Jancarek (1998)
J. Immunol. 161, 3237-3241
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A Cytokine Cascade Including Prostaglandin E2, IL-4, and IL-10 Is Responsible for UV-Induced Systemic Immune Suppression.
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J. Immunol. 160, 3783-3789
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The Molecular Basis of Nonmelanoma Skin Cancer: New Understanding.
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Arch Dermatol 133, 1263-1270
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The inhibition of antigen-presenting activity of dendritic cells resulting from UV irradiation of murine skin is restored by in vitro photorepair of cyclobutane pyrimidine dimers.
A. A. Vink, A. M. Moodycliffe, V. Shreedhar, S. E. Ullrich, L. Roza, D. B. Yarosh, and M. L. Kripke (1997)
PNAS 94, 5255-5260
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Is Favorable Prognosis of Squamous Cell Carcinoma of the Skin Due to Efficient Immune Surveillance?.
J. Smolle and P. Wolf (1997)
Arch Dermatol 133, 645-646
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Final Report on the Safety Assessment of Urocanic Acid.
(1995)
International Journal of Toxicology 14, 386-423
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Evidence That Sunscreens Prevent UV Radiation-Induced Immunosuppression in Humans: Sunscreens Have Their Day in the Sun.
R. D. Granstein (1995)
Arch Dermatol 131, 1201-1204
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Role of Excision Repair in UVB-Induced Depletion and Recovery of Human Epidermal Langerhans Cells.
T. Jimbo, M. Ichihashi, Y. Mishima, and Y. Fujiwara (1992)
Arch Dermatol 128, 61-67
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In Vivo Ultraviolet Irradiation of Human Skin Results in Profound Perturbation of the Immune System: Relevance to Ultraviolet-Induced Skin Cancer.
O. Baadsgaard (1991)
Arch Dermatol 127, 99-109
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Immunologic inhibition of ultraviolet radiation-induced tumor suppressor cell activity.
R. Granstein, J. Parrish, D. McAuliffe, C Waltenbaugh, and M. Greene (1984)
Science 224, 615-617
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Antigenic similarity between cells transformed by ultraviolet radiation in vitro and in vivo.
M. Fisher, M. Kripke, and G. Chan (1984)
Science 223, 593-594
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UV irradiation augments lymphoid malignancies in mice with one functional copy of wild-type p53.
W. Jiang, H. N. Ananthaswamy, H. K. Muller, A. Ouhtit, S. Bolshakov, S. E. Ullrich, A. K. El-Naggar, and M. L. Kripke (2001)
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