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Science 28 May 1982:
Vol. 216. no. 4549, pp. 1020 - 1021
DOI: 10.1126/science.6805074
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Articles

Science, Vol 216, Issue 4549, 1020-1021
Copyright © 1982 by American Association for the Advancement of Science

articles

Interference with dimethylhydrazine induction of colon tumors in mice by epsilon-aminocaproic acid

JG Corasanti, GH Hobika, and G Markus

The antifibrinolytic agent epsilon-aminocaproic acid given in the drinking water to Swiss ICR/Ha mice significantly counteracted the appearance of colorectal tumors induced by 21 weekly infections of 1,2-dimethylhydrazine. The drug affected both the number and the location of the tumors and, in some animals, altogether prevented their appearance. The low concentrations of epsilon-aminocaproic acid in the plasma of four control mice given the agent labeled with carbon-14 for 3 days suggest that the effect may depend not on inhibition of plasminogen activator activity, but on interference with the binding of some substance to the strong lysine binding site of plasminogen.


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Basic Fibroblast Growth Factor–Induced Angiogenic Phenotype in Mouse Endothelium : A Study of Aortic and Microvascular Endothelial Cell Lines.
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