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Science 28 May 1982:
Vol. 216. no. 4549, pp. 1012 - 1014
DOI: 10.1126/science.6805073
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Articles

Science, Vol 216, Issue 4549, 1012-1014
Copyright © 1982 by American Association for the Advancement of Science

articles

Serotonin and octopamine in the nematode Caenorhabditis elegans

HR Horvitz, M Chalfie, C Trent, JE Sulston, and PD Evans

The biogenic amines serotonin and octopamine are present in the nematode Caenorhabditis elegans. Serotonin, detected histochemically in whole mounts, is localized in two pharyngeal neurons that appear to be neurosecretory. Octopamine, identified radioenzymatically in crude extracts, probably is also localized in a few neurons. Exogenous serotonin and octopamine elicit specific and opposite behavioral responses in Caenorhabditis elegans, suggesting that these compounds function physiologically as antagonists.


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Neuronal Cell Lineages in the Nematode Caenorhabditis elegans.
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