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Science 28 May 1982:
Vol. 216. no. 4549, pp. 1010 - 1012
DOI: 10.1126/science.7079746
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Articles

Science, Vol 216, Issue 4549, 1010-1012
Copyright © 1982 by American Association for the Advancement of Science

articles

Inability of oxytocin to activate pyruvate dehydrogenase in the Brattleboro rat

K Hanif, K Lederis, MD Hollenberg, and HJ Goren

Oxytocin has insulin-like activity in that it stimulates lipogenesis and increases pyruvate dehydrogenase activity. However, in adipocytes from homozygous Brattleboro rats oxytocin is incapable of stimulating lipogenesis or pyruvate dehydrogenase activity, although insulin stimulation of both processes is normal and the antilipolytic activity of oxytocin is normal. Thus, the Brattleboro rat provides a new genetic model for the study of oxytocin action, wherein recognition of the chemical mediator is partially defective.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Oxytocin Receptor System: Structure, Function, and Regulation.
G. Gimpl and F. Fahrenholz (2001)
Physiol Rev 81, 629-683
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