Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 28 May 1982:
Vol. 216. no. 4549, pp. 1003 - 1005
DOI: 10.1126/science.7079745
Prev | Table of Contents | Next

Articles

Science, Vol 216, Issue 4549, 1003-1005
Copyright © 1982 by American Association for the Advancement of Science

articles

Decreased nocturnal plasma melatonin peak in patients with estrogen receptor positive breast cancer

L Tamarkin, D Danforth, A Lichter, E DeMoss, M Cohen, B Chabner, and M Lippman

Plasma melatonin concentrations were determined over a period of 24 hours in 20 women with clinical stage I or II breast cancer. In ten of the patients, whose tumors were estrogen receptor positive, the nocturnal increase in plasma melatonin was much lower than that observed in eight control subjects. Women with the lowest peak concentration of melatonin had tumors with the highest concentrations of estrogen receptors. A significant correlation was found between the peak plasma melatonin concentration and the tumor estrogen receptor concentration in 19 of the patients. These data suggest that low nocturnal melatonin concentrations may indicate the presence of estrogen receptor positive breast cancer and could conceivably have etiologic significance.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Urinary Melatonin Levels and Postmenopausal Breast Cancer Risk in the Nurses' Health Study Cohort.
E. S. Schernhammer and S. E. Hankinson (2009)
Cancer Epidemiol. Biomarkers Prev. 18, 74-79
   Abstract »    Full Text »    PDF »
Melatonin as a Biomarker of Circadian Dysregulation.
D. K. Mirick and S. Davis (2008)
Cancer Epidemiol. Biomarkers Prev. 17, 3306-3313
   Abstract »    Full Text »    PDF »
Therapeutic Actions of Melatonin in Cancer: Possible Mechanisms.
V. Srinivasan, D W. Spence, S. R. Pandi-Perumal, I. Trakht, and D. P. Cardinali (2008)
Integr Cancer Ther 7, 189-203
   Abstract »    PDF »
Urinary 6-Sulfatoxymelatonin Levels and Risk of Breast Cancer in Postmenopausal Women.
E. S. Schernhammer, F. Berrino, V. Krogh, G. Secreto, A. Micheli, E. Venturelli, S. Sieri, C. T. Sempos, A. Cavalleri, H. J. Schunemann, et al. (2008)
J Natl Cancer Inst 100, 898-905
   Abstract »    Full Text »    PDF »
Prospective Cohort Study of the Risk of Prostate Cancer among Rotating-Shift Workers: Findings from the Japan Collaborative Cohort Study.
T. Kubo, K. Ozasa, K. Mikami, K. Wakai, Y. Fujino, Y. Watanabe, T. Miki, M. Nakao, K. Hayashi, K. Suzuki, et al. (2006)
Am. J. Epidemiol. 164, 549-555
   Abstract »    Full Text »    PDF »
Shift Work, Light at Night, and Breast Cancer on Long Island, New York.
E. S. O'Leary, E. R. Schoenfeld, R. G. Stevens, G. C. Kabat, K. Henderson, R. Grimson, M. D. Gammon, M. C. Leske, and for the Electromagnetic Fields and Breast Cancer o (2006)
Am. J. Epidemiol. 164, 358-366
   Abstract »    Full Text »    PDF »
A prospective study on habitual duration of sleep and incidence of breast cancer in a large cohort of women..
S. P. Pinheiro, E. S. Schernhammer, S. S. Tworoger, and K. B. Michels (2006)
Cancer Res. 66, 5521-5525
   Abstract »    Full Text »    PDF »
Urinary Melatonin Levels and Breast Cancer Risk.
E. S. Schernhammer and S. E. Hankinson (2005)
J Natl Cancer Inst 97, 1084-1087
   Abstract »    Full Text »    PDF »
Melatonin and Breast Cancer: A Prospective Study.
R. C. Travis, D. S. Allen, I. S. Fentiman, and T. J. Key (2004)
J Natl Cancer Inst 96, 475-482
   Abstract »    Full Text »    PDF »
Alcohol exposure in utero and breast cancer risk later in life.
R. G. Stevens and L. Hilakivi-Clarke (2001)
Alcohol Alcohol. 36, 276-277
   Full Text »    PDF »
Annual Rhythm in the Growth of Human Breast Carcinomas as Reflected in the Histology of Their Growing Edge.
F. Hartveit (2000)
International Journal of Surgical Pathology 8, 39-47
   Abstract »    PDF »
Melatonin in Humans.
A. Brzezinski (1997)
N. Engl. J. Med. 336, 186-195
   Full Text »    PDF »
Possible Association Between Breast Cancer and Malignant Melanoma.
H. Arbesman and T. Byers (1988)
Arch Dermatol 124, 1007
   Abstract »    PDF »
Melatonin: a coordinating signal for mammalian reproduction?.
L Tamarkin, C. Baird, and O. Almeida (1985)
Science 227, 714-720
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)