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Science 21 May 1982:
Vol. 216. no. 4548, pp. 892 - 894
DOI: 10.1126/science.6281883
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Articles

Science, Vol 216, Issue 4548, 892-894
Copyright © 1982 by American Association for the Advancement of Science

articles

Cytomegalovirus antibody in cerebrospinal fluid of schizophrenic patients detected by enzyme immunoassay

EF Torrey, RH Yolken, and CJ Winfrey

By means of enzyme immunoassay techniques to detect the presence of antibody to cytomegalovirus, the cerebrospinal fluid of 178 patients with schizophrenia, 17 patients with bipolar disorders, and 11 other psychiatric patients was compared with that of 79 neurological patients and 41 normal control subjects. The cerebrospinal fluid of 20 of the schizophrenic patients and 3 of the patients with bipolar disorders showed significant increases in immunoglobulin M antibody to cytomegalovirus; no difference was found in patients on or off psychotropic medications.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Results From a Hypothesis Generating Case-Control Study: Herpes Family Viruses and Schizophrenia Among Military Personnel.
D. W. Niebuhr, A. M. Millikan, R. Yolken, Y. Li, and N. S. Weber (2008)
Schizophr Bull 34, 1182-1188
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Selected Infectious Agents and Risk of Schizophrenia Among U.S. Military Personnel.
D. W. Niebuhr, A. M. Millikan, D. N. Cowan, R. Yolken, Y. Li, and N. S. Weber (2008)
Am J Psychiatry 165, 99-106
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Search for Viral Nucleic Acid Sequences in Brain Tissues of Patients With Schizophrenia Using Nested Polymerase Chain Reaction.
A. M. Taller, D. M. Asher, K. L. Pomeroy, B. A. Eldadah, M. S. Godec, P. G. Falkai, B. Bogert, J. E. Kleinman, J. R. Stevens, and E. F. Torrey (1996)
Arch Gen Psychiatry 53, 32-40
   Abstract »    PDF »
Search for Cytomegalovirus in the Postmortem Brains of Schizophrenic Patients Using the Polymerase Chain Reaction.
R. C. Alexander, S. A. Spector, M. Casanova, J. Kleinman, R. J. Wyatt, and D. G. Kirch (1992)
Arch Gen Psychiatry 49, 47-53
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Intracerebral Inoculation of Experimental Animals With Brain Tissue From Patients With Schizophrenia: Failure to Observe Consistent or Specific Behavioral and Neuropathological Effects.
C. A. Kaufmann, D. R. Weinberger, J. R. Stevens, D. M. Asher, J. E. Kleinman, M. P. Sulima, C. J. Gibbs Jr, and D. C. Gajdusek (1988)
Arch Gen Psychiatry 45, 648-652
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A Search for Cytomegalovirus and Herpes Viral Antigen in Brains of Schizophrenic Patients.
J. R. Stevens, J. M. Langloss, P. Albrecht, R. Yolken, and Y.-N. Wang (1984)
Arch Gen Psychiatry 41, 795-801
   Abstract »    PDF »
Human Cytomegalovirus Infection and Disorders of the Nervous System.
J. F. Bale Jr (1984)
Arch Neurol 41, 310-320
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Dopamine-beta-hydroxylase activity and homovanillic acid in spinal fluid of schizophrenics with brain atrophy.
D. van Kammen, L. Mann, D. Sternberg, M Scheinin, P. Ninan, Marder SR, W. van Kammen, R. Rieder, and M Linnoila (1983)
Science 220, 974-977
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