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Science 14 May 1982:
Vol. 216. no. 4547, pp. 759 - 761
DOI: 10.1126/science.7079739
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Articles

Science, Vol 216, Issue 4547, 759-761
Copyright © 1982 by American Association for the Advancement of Science

articles

Early chronic low-level methylmercury poisoning in monkeys impairs spatial vision

DC Rice and SG Gilbert

Five monkeys were treated from birth with oral doses of mercury as methylmercury (50 micrograms per kilogram of body weight per day); concentrations in the blood peaked at 1.2 to 1.4 parts per million; and declined after weaning from infant formula to a steady level of 0.6 to 0.9 part per million. There were no overt signs of toxicity. When tested between 3 and 4 years of age under conditions of both high and low luminance, treated monkeys exhibited spatial vision that was impaired compared with that of control monkeys.


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Determination of a site-specific reference dose for methylmercury for fish-eating populations.
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