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Science 14 May 1982:
Vol. 216. no. 4547, pp. 745 - 747
DOI: 10.1126/science.7079735
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Articles

Science, Vol 216, Issue 4547, 745-747
Copyright © 1982 by American Association for the Advancement of Science

articles

Cellular mechanism of neuronal synchronization in epilepsy

RD Traub and RK Wong

Interictal spikes are a simple kind of epileptic neuronal activity. Field potentials and intracellular recordings observed during interictal spikes of penicillin-treated slices of the hippocampus were reproduced by a mathematical model of a network of 100 hippocampal neurons from the region including CA2 and CA3. The model shows that this form of neuronal synchronization arises because of mutual excitation between neurons, each of which is capable of intrinsic bursting in response to a brief input.


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Upregulation of a T-Type Ca2+ Channel Causes a Long-Lasting Modification of Neuronal Firing Mode after Status Epilepticus.
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Short- and Long-Term Changes in CA1 Network Excitability After Kainate Treatment in Rats.
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Epileptiform Activity Can Be Initiated in Various Neocortical Layers: An Optical Imaging Study.
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Glutamate Receptors Mediate TTX-Resistant Synchronous Activity in the Rat Hippocampus.
B. W. Strowbridge (1999)
J. Neurosci. 19, 5758-5767
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Nonlinear Frequency-Dependent Synchronization in the Developing Hippocampus.
L. M. d. l. Prida and J. V. Sanchez-Andres (1999)
J Neurophysiol 82, 202-208
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Somatostatin Acts in CA1 and CA3 to Reduce Hippocampal Epileptiform Activity.
M. K. Tallent and G. R. Siggins (1999)
J Neurophysiol 81, 1626-1635
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Focal Epileptogenesis in a Rat Model of Polymicrogyria.
K. M. Jacobs, B. J. Hwang, and D. A. Prince (1999)
J Neurophysiol 81, 159-173
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Activity-Dependent pH Shifts and Periodic Recurrence of Spontaneous Interictal Spikes in a Model of Focal Epileptogenesis.
M. de Curtis, A. Manfridi, and G. Biella (1998)
J. Neurosci. 18, 7543-7551
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Limbic Gamma Rhythms. I. Phase-Locked Oscillations in Hippocampal CA1 and Subiculum.
S. B. Colling, I. M. Stanford, R. D. Traub, and J. G. R. Jefferys (1998)
J Neurophysiol 80, 155-161
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Properties of {gamma}-frequency oscillations initiated by propagating population bursts in retrohippocampal regions of rat brain slices.
M. Funahashi and M. Stewart (1998)
J. Physiol. 510, 191-208
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Laminar organization of epileptiform discharges in the rat entorhinal cortex in vitro.
V. Lopantsev and M. Avoli (1998)
J. Physiol. 509, 785-796
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Physiological Unmasking of New Glutamatergic Pathways in the Dentate Gyrus of Hippocampal Slices From Kainate-Induced Epileptic Rats.
P. R. Patrylo and F. E. Dudek (1998)
J Neurophysiol 79, 418-429
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CA3-Driven Hippocampal-Entorhinal Loop Controls Rather than Sustains In Vitro Limbic Seizures.
M. Barbarosie and M. Avoli (1997)
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Properties of Carbachol-Induced Oscillatory Activity in Rat Hippocampus.
J. H. Williams and J. A. Kauer (1997)
J Neurophysiol 78, 2631-2640
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Spontaneous Excitatory Currents and kappa -Opioid Receptor Inhibition in Dentate Gyrus Are Increased in the Rat Pilocarpine Model of Temporal Lobe Epilepsy.
M. L. Simmons, G. W. Terman, and C. Chavkin (1997)
J Neurophysiol 78, 1860-1868
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Propagating Neuronal Discharges in Neocortical Slices: Computational and Experimental Study.
D. Golomb and Y. Amitai (1997)
J Neurophysiol 78, 1199-1211
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Role of Group I Metabotropic Glutamate Receptors in the Patterning of Epileptiform Activities In Vitro.
L. R. Merlin and R. K. S. Wong (1997)
J Neurophysiol 78, 539-544
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Electrographic Seizures and New Recurrent Excitatory Circuits in the Dentate Gyrus of Hippocampal Slices from Kainate-Treated Epileptic Rats.
J.-P. Wuarin and F. E. Dudek (1996)
J. Neurosci. 16, 4438-4448
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Excitatory synaptic responses mediated by GABAA receptors in the hippocampus.
H. Michelson and R. Wong (1991)
Science 253, 1420-1423
   Abstract »    PDF »
Model of the origin of rhythmic population oscillations in the hippocampal slice.
R. Traub, R Miles, and R. Wong (1989)
Science 243, 1319-1325
   Abstract »    PDF »
Computing with neural circuits: a model.
J. Hopfield and D. Tank (1986)
Science 233, 625-633
   Abstract »    PDF »
Fast extracellular calcium transients: involvement in epileptic processes.
R Pumain, I Kurcewicz, and J Louvel (1983)
Science 222, 177-179
   Abstract »    PDF »
Synchronous neural afterdischarges in rat hippocampal slices without active chemical synapses.
C. Taylor and F. Dudek (1982)
Science 218, 810-812
   Abstract »    PDF »


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