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Science 7 May 1982:
Vol. 216. no. 4546, pp. 644 - 646
DOI: 10.1126/science.7041259
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Articles

Science, Vol 216, Issue 4546, 644-646
Copyright © 1982 by American Association for the Advancement of Science

articles

Neonatal thymectomy prevents spontaneous diabetes mellitus in the BB/W rat

AA Like, E Kislauskis, RR Williams, and AA Rossini

Complete neonatal thymectomy reduced the frequency of spontaneous diabetes mellitus in BioBreeding/Worcester rats from 27 to 3 percent. Incomplete thymectomy also significantly reduced the frequency of diabetes (to 9 percent). These findings strengthen the hypothesis that thymus-dependent, cell-mediated autoimmune destruction of pancreatic B cells is responsible for the pathogenesis of diabetes in this experimental animal.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
On the Edge of Autoimmunity: T-Cell Stimulation by Steady-State Dendritic Cells Prevents Autoimmune Diabetes.
D. Bruder, A. M. Westendorf, W. Hansen, S. Prettin, A. D. Gruber, Y. Qian, H. von Boehmer, K. Mahnke, and J. Buer (2005)
Diabetes 54, 3395-3401
   Abstract »    Full Text »    PDF »
Enteropathy precedes type 1 diabetes in the BB rat.
S Graham, P Courtois, W J Malaisse, J Rozing, F W Scott, and A M. I Mowat (2004)
Gut 53, 1437-1444
   Abstract »    Full Text »    PDF »
Thymectomy and Radiation-Induced Type 1 Diabetes in Nonlymphopenic BB Rats.
S. Ramanathan, M.-T. Bihoreau, A. D. Paterson, L. Marandi, D. Gauguier, and P. Poussier (2002)
Diabetes 51, 2975-2981
   Abstract »    Full Text »    PDF »
Role of T cells in development of chronic pancreatitis in male Wistar Bonn/Kobori rats: effects of tacrolimus.
T. Yamada, T. Hashimoto, M. Sogawa, S. Kobayashi, K. Kaneda, S. Nakamura, A. Kuno, H. Sano, T. Ando, S. Kobayashi, et al. (2001)
Am J Physiol Gastrointest Liver Physiol 281, G1397-G1404
   Abstract »    Full Text »    PDF »
Cellular and Molecular Mechanism for Kilham Rat Virus-Induced Autoimmune Diabetes in DR-BB Rats.
Y.-H. Chung, H. S. Jun, M. Son, M. Bao, H. Y. Bae, Y. Kang, and J.-W. Yoon (2000)
J. Immunol. 165, 2866-2876
   Abstract »    Full Text »    PDF »
T Cell Reconstitution of BB/W Rats After the Initiation of Insulitis Precipitates the Onset of Diabetes.
S. Ramanathan and P. Poussier (1999)
J. Immunol. 162, 5134-5142
   Abstract »    Full Text »    PDF »
The rat as an experimental animal.
T. Gill 3rd, G. Smith, R. Wissler, and H. Kunz (1989)
Science 245, 269-276
   Abstract »    PDF »
Transfusions of whole blood prevent spontaneous diabetes mellitus in the BB/W rat.
A. Rossini, J. Mordes, A. Pelletier, and A. Like (1983)
Science 219, 975-977
   Abstract »    PDF »


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