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Science 7 May 1982:
Vol. 216. no. 4546, pp. 637 - 639
DOI: 10.1126/science.7071604
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Articles

Science, Vol 216, Issue 4546, 637-639
Copyright © 1982 by American Association for the Advancement of Science

articles

Human aldehyde dehydrogenase: mechanism of inhibition of disulfiram

RC Vallari and R Pietruszko

Disulfiram labeled with carbon-14 reacts specifically with human liver aldehyde dehydrogenase E1 with loss of catalytic activity and no incorporation of label. Carbon-14-labeled diethyldithiocarbamate is formed and the number of enzyme sulfhydryl groups decreases from 34 to 30 during this process.Activity is recovered by-mercaptoethanol but not by glutathione, the physiological reducing agent.


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