Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 7 May 1982:
Vol. 216. no. 4546, pp. 637 - 639
DOI: 10.1126/science.7071604
Prev | Table of Contents | Next

Articles

Science, Vol 216, Issue 4546, 637-639
Copyright © 1982 by American Association for the Advancement of Science

articles

Human aldehyde dehydrogenase: mechanism of inhibition of disulfiram

RC Vallari and R Pietruszko

Disulfiram labeled with carbon-14 reacts specifically with human liver aldehyde dehydrogenase E1 with loss of catalytic activity and no incorporation of label. Carbon-14-labeled diethyldithiocarbamate is formed and the number of enzyme sulfhydryl groups decreases from 34 to 30 during this process.Activity is recovered by-mercaptoethanol but not by glutathione, the physiological reducing agent.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Retinoic acid signaling sensitizes hepatic stellate cells to NK cell killing via upregulation of NK cell activating ligand RAE1.
S. Radaeva, L. Wang, S. Radaev, W.-I. Jeong, O. Park, and B. Gao (2007)
Am J Physiol Gastrointest Liver Physiol 293, G809-G816
   Abstract »    Full Text »    PDF »
Phenylacetaldehyde Oxidation by Freshly Prepared and Cryopreserved Guinea Pig Liver Slices: The Role of Aldehyde Oxidase.
G. I. Panoutsopoulos (2005)
International Journal of Toxicology 24, 103-109
   Abstract »    Full Text »    PDF »
From the Cover: Identification of the enzymatic mechanism of nitroglycerin bioactivation.
Z. Chen, J. Zhang, and J. S. Stamler (2002)
PNAS 99, 8306-8311
   Abstract »    Full Text »    PDF »
PARADIGM TO TEST A DRUG-INDUCED AVERSION TO ETHANOL.
E. Garver, A. D. Ross, G.-C. Tu, Q.-N. Cao, F. Zhou, and Y. Israel (2000)
Alcohol Alcohol. 35, 435-438
   Abstract »    Full Text »    PDF »
Segment-specific pattern of sympathetic preganglionic projections in the chicken embryo spinal cord is altered by retinoids.
C. J. Forehand, E. B. Ezerman, J. P. Goldblatt, D. L. Skidmore, and J. C. Glover (1998)
PNAS 95, 10878-10883
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)