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Science 30 April 1982:
Vol. 216. no. 4545, pp. 542 - 545
DOI: 10.1126/science.7041258
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Articles

Science, Vol 216, Issue 4545, 542-545
Copyright © 1982 by American Association for the Advancement of Science

articles

Autoantibodies to insulin receptor spontaneously develop as anti-idiotypes in mice immunized with insulin

Y Shechter, R Maron, D Elias, and IR Cohen

Mice immunized with insulin developed antibodies to both insulin and the insulin receptor. The antibodies to insulin receptor displaced labeled insulin from insulin receptors and mimicked the actions of insulin in stimulating the oxidation of glucose and its incorporation into lipids, and in inhibiting lipolysis. The antibodies to insulin receptor could be blocked by or bound to the antibodies to insulin, and therefore were identified as anti-idiotypes. Thus, immunization against a hormone may activate spontaneously an idiotype-anti-idiotype network resulting in antibodies to the hormone receptor.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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T. Hiesberger, R. Hodits, R. Ullrich, M. Exner, D. Kerjaschki, W. J. Schneider, and J. Nimpf (1996)
J. Biol. Chem. 271, 28792-28797
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Review : Variable regions of two murine antibodies that bind the SLE associated 16/6 idiotype.
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Lupus 5, 279-287
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Physiological Basis of T-cell Vaccination against Autoimmune Disease.
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Cold Spring Harb Symp Quant Biol 54, 879-884
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Antisomatostatin IgG in Major Depressive Disorder: A Preliminary Study With Implications for an Autoimmune Mechanism of Depression.
B. F. Roy, J. W. Rose, T. Sunderland, J. M. Morihisa, and D. L. Murphy (1988)
Arch Gen Psychiatry 45, 924-928
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