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Science 30 April 1982:
Vol. 216. no. 4545, pp. 535 - 537
DOI: 10.1126/science.7071600
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Articles

Science, Vol 216, Issue 4545, 535-537
Copyright © 1982 by American Association for the Advancement of Science

articles

Lysergic acid diethylamide (LSD) and lisuride: differentiation of their neuropharmacological actions

FJ White and JB Appel

The nonhallucinogenic ergot derivative lisuride exerts many pharmacological effects that are similar to those of its hallucinogenic congener, lysergic acid diethylamide (LSD). Animals trained to discriminate between the presence of one drug and the other can be used to differentiate the actions of these compounds on a neuronal level. The discriminative stimulus effect of LSD (the LSD cue) is similar to that of the serotonin agonist quipazine, whereas the lisuride cue is similar to that of the dopamine agonist apomorphine. These data support the hypothesis that serotonin is intricately involved in the hallucinogenic effects of LSD.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Transcriptome Fingerprints Distinguish Hallucinogenic and Nonhallucinogenic 5-Hydroxytryptamine 2A Receptor Agonist Effects in Mouse Somatosensory Cortex.
J. Gonzalez-Maeso, T. Yuen, B. J. Ebersole, E. Wurmbach, A. Lira, M. Zhou, N. Weisstaub, R. Hen, J. A. Gingrich, and S. C. Sealfon (2003)
J. Neurosci. 23, 8836-8843
   Abstract »    Full Text »    PDF »
Childhood Near-Death Experiences.
M. Morse, P. Castillo, D. Venecia, J. Milstein, and D. C. Tyler (1986)
Arch Pediatr Adolesc Med 140, 1110-1114
   Abstract »    PDF »


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