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Science 30 April 1982:
Vol. 216. no. 4545, pp. 531 - 533
DOI: 10.1126/science.6176025
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Articles

Science, Vol 216, Issue 4545, 531-533
Copyright © 1982 by American Association for the Advancement of Science

articles

Relaxation of isolated gastric smooth muscle cells by vasoactive intestinal peptide

KN Bitar and GM Makhlouf

Vasoactive intestinal peptide caused a prompt, dose-dependent relaxation of isolated gastric smooth muscle cells of the guinea pig and a significant increase in intracellular adenosine 3',5'-monophosphate coincidentally with optimum relaxation. Relaxation was augmented by a threshold concentration of isobutyl methylxanthine. The direct relaxant effect of vasoactive intestinal peptide and the distribution of nerves containing this peptide to circular smooth muscle support the view that vasoactive intestinal peptide is the neuromuscular transmitter of enteric inhibitory nerves.


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