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Science 30 April 1982:
Vol. 216. no. 4545, pp. 529 - 531
DOI: 10.1126/science.6461921
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Articles

Science, Vol 216, Issue 4545, 529-531
Copyright © 1982 by American Association for the Advancement of Science

articles

The molecules that initiate cardiac hypertrophy are not species-specific

GL Hammond, YK Lai, and CL Markert

Extracts from hypertrophying dog hearts perfused through isolated rat hearts increase the synthesis of messenger RNA and initiate hypertrophy in the treated hearts. Total RNA extracted from experimental and control hearts was translated in vitro and hybridized with polyuridylate. Synthesis of protein and polyadenylate-containing RNA was greater in rat hearts perfused with extracts of hypertrophying dog hearts than in control hearts. The results demonstrate that molecules from hypertrophying dog hearts are not species-specific since they are effective in stimulating transcription of messenger RNA in rat hearts as well as in dog hearts.


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