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Science 30 April 1982:
Vol. 216. no. 4545, pp. 527 - 529
DOI: 10.1126/science.6280280
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Articles

Science, Vol 216, Issue 4545, 527-529
Copyright © 1982 by American Association for the Advancement of Science

articles

A new tumor-promoting agent, dihydroteleocidin B, markedly enhances chemically induced malignant cell transformation

T Hirakawa, T Kakunaga, H Fujiki, and T Sugimura

Teleocidin, which was isolated from mycelia of Streptomyces, is a potent tumor promoter in mouse skin. The catalytically hydrogenated compound dihydroteleocidin B markedly enhanced malignant cell transformation induced by 3-methylcholanthrene or ultraviolet radiation. Dihydroteleocidin B was at least 100 times more effective in enhancing transformation than 12-O-tetradecanoyl phorbol-13-acetate, the strongest promoter known until now, whereas both promoters showed equal capacities to induce early membrane effects and DNA synthesis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Enhancement of Transformed Foci and Induction of Prostaglandins in Balb/c 3T3 Cells by Palytoxin: In Vitro Model Reproduces Carcinogenic Responses in Animal Models Regarding the Inhibitory Effect of Indomethacin and Reversal of Indomethacin's Effect by Exogenous Prostaglandins.
D. Miura, M. Kobayashi, S. Kakiuchi, Y. Kasahara, and S. Kondo (2006)
Toxicol. Sci. 89, 154-163
   Abstract »    Full Text »    PDF »
Bromine residue at hydrophilic region influences biological activity of aplysiatoxin, a tumor promoter.
K Shimomura, M. Mullinix, T Kakunaga, H Fujiki, and T Sugimura (1983)
Science 222, 1242-1244
   Abstract »    PDF »


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