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Science 30 April 1982:
Vol. 216. no. 4545, pp. 523 - 525
DOI: 10.1126/science.7071598
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Articles

Science, Vol 216, Issue 4545, 523-525
Copyright © 1982 by American Association for the Advancement of Science

articles

Myoglobin function in exercising skeletal muscle

RP Cole

Short-term perfusion of the isolated dog gastrocnemius-plantaris muscle with hydrogen peroxide resulted in a decrease in steady-state muscle oxygen consumption and isometric tension generation. Hydrogen peroxide converted intracellular myoglobin to products incapable of combination with oxygen, but had no deleterious effect on neuromuscular transmission or on mitochondrial oxidative phosphorylation. It is concluded that functional intracellular myoglobin is important in maintaining oxygen consumption and tension generation in exercising skeletal muscle.


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