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Science 23 April 1982:
Vol. 216. no. 4544, pp. 436 - 437
DOI: 10.1126/science.7200260
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Articles

Science, Vol 216, Issue 4544, 436-437
Copyright © 1982 by American Association for the Advancement of Science

articles

Heroin "overdose" death: contribution of drug-associated environmental cues

S Siegel, RE Hinson, MD Krank, and J McCully

A model of "overdose" deaths among heroin addicts is proposed which emphasizes recent findings concerning the contribution of drug-associated environmental cues to drug tolerance. Results of animal experiments performed to evaluate this model suggest that conditioned drug-anticipatory responses, in addition to pharmacological factors, affect heroin-induced mortality.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Absence of cross-tolerance and the situational specificity of tolerance.
S. Siegel and J. A Kim (2000)
Palliative Medicine 14, 75-77
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Multiple chemical sensitivity as a conditional response.
S. Siegel (1999)
Toxicology and Industrial Health 15, 323-330
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)