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Science 23 April 1982:
Vol. 216. no. 4544, pp. 427 - 429
DOI: 10.1126/science.6280279
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Articles

Science, Vol 216, Issue 4544, 427-429
Copyright © 1982 by American Association for the Advancement of Science

articles

Experimental hepatic encephalopathy: changes in the binding of gamma-aminobutyric acid

M Baraldi and ZL Zeneroli

Two populations of receptors for gamma-aminobutyric acid, one with low- and the other with high-affinity characteristics, are detectable in frozen, thawed, Triton-treated synaptic membrane preparations from normal brain. It is now reported that membrane preparations from rats with mild galactosamine-induced hepatic encephalopathy show an increase in the number of low- and high-affinity gamma-aminobutyric acid binding sites, whereas those from rats with severe encephalopathy show only high-affinity binding sites. Thus, hepatic encephalopathy appears to involve partial degeneration of the gamma-aminobutyric acid-containing presynaptic nerve terminals.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Olfactory Deficits in Patients Affected by Minimal Hepatic Encephalopathy: A Pilot Study.
G. M. Zucco, P. Amodio, and A. Gatta (2006)
Chem Senses 31, 273-278
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The {gamma}-Aminobutyric Acid A (GABAA) Receptor Complex and Hepatic Encephalopathy: Some Recent Advances.
E. A. Jones, P. Skolnick, S. H. Gammal, A. S. Basile, and K. D. Mullen (1989)
Ann Intern Med 110, 532-546
   Abstract »    PDF »


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