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Science 23 April 1982:
Vol. 216. no. 4544, pp. 422 - 424
DOI: 10.1126/science.7071591
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Articles

Science, Vol 216, Issue 4544, 422-424
Copyright © 1982 by American Association for the Advancement of Science

articles

Synaptic cleft glycoproteins contain homologous amino acid sequences

EE Mena and CW Cotman

The concanavalin A--binding glycoproteins of the rat synaptic junction were isolated by affinity chromatography. These glycoproteins had molecular weights of 160,000, 123,000, 110,000, and 95,000. The tryptic peptide maps of these glycoproteins showed that the three largest glycoproteins contained a high percentage of identical peptides. This indicates that the amino acid sequences of these glycoproteins have a high degree of homology. The 95,000-dalton glycoprotein was unrelated to the other three. These findings suggest that homologous glycoproteins may participate in synapse formation or maintenance, or both.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)