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Science 23 April 1982:
Vol. 216. no. 4544, pp. 417 - 419
DOI: 10.1126/science.7071590
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Articles

Science, Vol 216, Issue 4544, 417-419
Copyright © 1982 by American Association for the Advancement of Science

articles

Calcium and age in fibroblasts from control subjects and patients with cystic fibrosis

BL Shapiro and LF Lam

Intracellular calcium increases significantly as human fibroblasts age in culture. The calcium increase occurs 5 to 6 weeks (passages) earlier and is significantly greater in fibroblasts from subjects with cystic fibrosis in comparison with cells from control subjects. Intracellular calcium, which is thought to be a pathogenetic factor in cystic fibrosis, may also be a meaningful marker in cell aging.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)