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Science 23 April 1982:
Vol. 216. no. 4544, pp. 409 - 411
DOI: 10.1126/science.6176023
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Articles

Science, Vol 216, Issue 4544, 409-411
Copyright © 1982 by American Association for the Advancement of Science

articles

Substance P and cholecystokinin-like peptides in Helix neurons and cholecystokinin and serotonin in a giant neuron

NN Osborne, AC Cuello, and GJ Dockray

Immunohistochemical procedures revealed that the serotonin-containing cell situated in each metacerebral ganglion of the snail Helix also contains a cholecystokinin-like peptide, but is devoid of substance P. In radioimmunoassays the cholecystokinin-like material showed similarities to the carboxy terminal regions of mammalian cholecystokinin and gastrin. Since much is known about the morphology and synaptic connections of this serotonin neuron, the role of the cholecystokinin-like peptides can now be investigated by neurophysiological methods, thus opening the way to discovering whether a neuron can use more than one transmitter.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Serotonergic Neurons Differentially Modulate the Efficacy of Two Motor Neurons Innervating the Same Muscle Fibers in Aplysia.
L. E. Fox and P. E. Lloyd (1998)
J Neurophysiol 80, 647-655
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Science. ISSN 0036-8075 (print), 1095-9203 (online)