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Science 16 April 1982:
Vol. 216. no. 4543, pp. 311 - 313
DOI: 10.1126/science.7063889
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Articles

Science, Vol 216, Issue 4543, 311-313
Copyright © 1982 by American Association for the Advancement of Science

articles

Decreased insulin receptors but normal glucose metabolism in Duchenne muscular dystrophy

R DePirro, R Lauro, I Testa, I Ferretti, C De Martinis, and R Dellatonio

Compared to matched controls, 17 patients with Duchenne muscular dystrophy showed decreased insulin binding to monocytes due to decreased receptor concentration. These patients showed no signs of altered glucose metabolism and retrospective analysis of the clinical records of a further 56 such patients revealed no modification in carbohydrate metabolism. These data suggest that reduced insulin receptor number does not produce overt modifications of glucose metabolism in Duchenne muscular dystrophy.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)