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Science 16 April 1982:
Vol. 216. no. 4543, pp. 307 - 308
DOI: 10.1126/science.7063888
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Articles

Science, Vol 216, Issue 4543, 307-308
Copyright © 1982 by American Association for the Advancement of Science

articles

X-ray induction of persistent hypersensitivity to mutation

JP Frank and Williams JR

The progeny of x-irradiated V79 cells are hypersensitive to PUVA-(8-methoxypsoralen plus longwave ultraviolet light) induced mutation at the locus for hypoxanthine-guanine phosphoribosyl transferase. This hypersensitivity is most evident at low doses of pUVA that do not induce mutation in non-x-irradiated cells. The hypersensitivity is evoked by x-irradiation delivered as a single dose or as multiple fractions over a long period and persists for at least 108 days of exponential growth. This radiation-induced hypersensitivity to subsequent mutation is a new phenomenon that may be relevant to multistage carcinogenesis.


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Ubiquitous, heritable damage in cell populations that survive treatment with methotrexate.
M. Chow and H. Rubin (1997)
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Dose Patterns of Cellular Effects Induced by Carcinogens: Evidence for the Presence or Absence of Thresholds.
J. R. Williams and P. D'Arpa (1983)
International Journal of Toxicology 2, 185-193
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