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Science 9 April 1982:
Vol. 216. no. 4542, pp. 196 - 198
DOI: 10.1126/science.7063880
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Articles

Science, Vol 216, Issue 4542, 196-198
Copyright © 1982 by American Association for the Advancement of Science

articles

Bronchoconstrictor effects of leukotriene C in humans

JW Weiss, JM Drazen, N Coles, ER McFadden Jr, PF Weller, EJ Corey, RA Lewis, and KF Austen

Maximum expiratory flow rate at 30 percent of vital capacity above residual volume served as an index of airway obstruction in comparing the effects of leukotriene C and histamine administered by aerosol to five normal persons. Leukotriene C was 600 to 9500 times more potent than histamine on a molar basis in producing an equivalent decrement in the residual volume. The leukotriene C response was slow in onset and prolonged, reminiscent of the effects of aerosol allergen challenge in asthmatic allergic subjects.


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