Science 9 April 1982: Vol. 216. no. 4542, pp. 136 - 144 DOI: 10.1126/science.6801762

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Articles

A collaborative Canadian-United Kingdom evaluation of an immunohistochemistry protocol to diagnose bovine spongiform encephalopathy.

L. Manning, K. I. O'Rourke, D. P. Knowles, S. A. Marsh, Y. I. Spencer, E. Moffat, G. A.H. Wells, and S. Czub (2008)
J Vet Diagn Invest 20, 504-508
 |  Abstract »  |  Full Text »  |  PDF »

A Regulatory Role of the Rnq1 Nonprion Domain for Prion Propagation and Polyglutamine Aggregates.

H. Kurahashi, M. Ishiwata, S. Shibata, and Y. Nakamura (2008)
Mol. Cell. Biol. 28, 3313-3323
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid Fibrils of the HET-s(218-289) Prion Form a {beta} Solenoid with a Triangular Hydrophobic Core.

C. Wasmer, A. Lange, H. Van Melckebeke, A. B. Siemer, R. Riek, and B. H. Meier (2008)
Science 319, 1523-1526
 |  Abstract »  |  Full Text »  |  PDF »

Conformational pH dependence of intermediate states during oligomerization of the human prion protein.

R. Gerber, A. Tahiri-Alaoui, P.J. Hore, and W. James (2008)
Protein Sci. 17, 537-544
 |  Abstract »  |  Full Text »  |  PDF »

The elk PRNP codon 132 polymorphism controls cervid and scrapie prion propagation.

K. M. Green, S. R. Browning, T. S. Seward, J. E. Jewell, D. L. Ross, M. A. Green, E. S. Williams, E. A. Hoover, and G. C. Telling (2008)
J. Gen. Virol. 89, 598-608
 |  Abstract »  |  Full Text »  |  PDF »

Protein Misfolding and Neurodegeneration.

C. Soto and L. D. Estrada (2008)
Arch Neurol 65, 184-189
 |  Abstract »  |  Full Text »  |  PDF »

Unraveling prion strains with cell biology and organic chemistry.

A. Aguzzi (2008)
PNAS 105, 11-12
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Decontamination of surgical instruments from prions. II. In vivo findings with a model system for testing the removal of scrapie infectivity from steel surfaces.

K. Lemmer, M. Mielke, C. Kratzel, M. Joncic, M. Oezel, G. Pauli, and M. Beekes (2008)
J. Gen. Virol. 89, 348-358
 |  Abstract »  |  Full Text »  |  PDF »

Selective Incorporation of Polyanionic Molecules into Hamster Prions.

J. C. Geoghegan, P. A. Valdes, N. R. Orem, N. R. Deleault, R. A. Williamson, B. T. Harris, and S. Supattapone (2007)
J. Biol. Chem. 282, 36341-36353
 |  Abstract »  |  Full Text »  |  PDF »

Influence of Water, Fat, and Glycerol on the Mechanism of Thermal Prion Inactivation.

H. Muller, L. Stitz, H. Wille, S. B. Prusiner, and D. Riesner (2007)
J. Biol. Chem. 282, 35855-35867
 |  Abstract »  |  Full Text »  |  PDF »

High Titers of Transmissible Spongiform Encephalopathy Infectivity Associated with Extremely Low Levels of PrPSc in Vivo.

R. M. Barron, S. L. Campbell, D. King, A. Bellon, K. E. Chapman, R. A. Williamson, and J. C. Manson (2007)
J. Biol. Chem. 282, 35878-35886
 |  Abstract »  |  Full Text »  |  PDF »

Medical Mineralogy and Geochemistry: An Interfacial Science.

N. Sahai (2007)
Elements 3, 381-384
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Dynamics Simulations of Two Tandem Octarepeats from the Mammalian Prion Protein: Fully Cu2+-bound and Metal-Free Forms.

M. J. Pushie and H. J. Vogel (2007)
Biophys. J. 93, 3762-3774
 |  Abstract »  |  Full Text »  |  PDF »

Role of Hsp104 in the Propagation and Inheritance of the [Het-s] Prion.

L. Malato, S. Dos Reis, L. Benkemoun, R. Sabate, and S. J. Saupe (2007)
Mol. Biol. Cell 18, 4803-4812
 |  Abstract »  |  Full Text »  |  PDF »

Molecular architecture of human prion protein amyloid: A parallel, in-register -structure.

N. J. Cobb, F. D. Sonnichsen, H. Mchaourab, and W. K. Surewicz (2007)
PNAS 104, 18946-18951
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Characterization of the Rocky Mountain Elk (Cervus elaphus nelsoni) PRNP Putative Promoter.

C. M. Seabury, C. A. Gill, J. W. Templeton, J. B. Dyar, J. N. Derr, D. L. Adelson, E. Owens, D. S. Davis, D. C. Kraemer, and J. E. Womack (2007)
J. Hered.
 |  Abstract »  |  Full Text »  |  PDF »

Mouse-Adapted Ovine Scrapie Prion Strains Are Characterized by Different Conformers of PrPSc.

A. M. Thackray, L. Hopkins, M. A. Klein, and R. Bujdoso (2007)
J. Virol. 81, 12119-12127
 |  Abstract »  |  Full Text »  |  PDF »

A General Model of Prion Strains and Their Pathogenicity.

J. Collinge and A. R. Clarke (2007)
Science 318, 930-936
 |  Abstract »  |  Full Text »  |  PDF »

PrPc Does Not Mediate Internalization of PrPSc but Is Required at an Early Stage for De Novo Prion Infection of Rov Cells.

S. Paquet, N. Daude, M.-P. Courageot, J. Chapuis, H. Laude, and D. Vilette (2007)
J. Virol. 81, 10786-10791
 |  Abstract »  |  Full Text »  |  PDF »

Polylactide-Coglycolide Microspheres CoEncapsulating Recombinant Tandem Prion Protein with CpG-Oligonucleotide Break Self-Tolerance to Prion Protein in Wild-Type Mice and Induce CD4 and CD8 T Cell Responses.

G. Kaiser-Schulz, A. Heit, L. Quintanilla-Martinez, F. Hammerschmidt, S. Hess, L. Jennen, H. Rezaei, H. Wagner, and H. M. Schatzl (2007)
J. Immunol. 179, 2797-2807
 |  Abstract »  |  Full Text »  |  PDF »

Species-specific Differences in the Intermediate States of Human and Syrian Hamster Prion Protein Detected by High Pressure NMR Spectroscopy.

W. Kremer, N. Kachel, K. Kuwata, K. Akasaka, and H. R. Kalbitzer (2007)
J. Biol. Chem. 282, 22689-22698
 |  Abstract »  |  Full Text »  |  PDF »

Hot spots in prion protein for pathogenic conversion.

K. Kuwata, N. Nishida, T. Matsumoto, Y. O. Kamatari, J. Hosokawa-Muto, K. Kodama, H. K. Nakamura, K. Kimura, M. Kawasaki, Y. Takakura, et al. (2007)
PNAS 104, 11921-11926
 |  Abstract »  |  Full Text »  |  PDF »

From the Cover: Formation of native prions from minimal components in vitro.

N. R. Deleault, B. T. Harris, J. R. Rees, and S. Supattapone (2007)
PNAS 104, 9741-9746
 |  Abstract »  |  Full Text »  |  PDF »

PrPSc in Salivary Glands of Scrapie-Affected Sheep.

M. Vascellari, R. Nonno, F. Mutinelli, M. Bigolaro, M. A. Di Bari, E. Melchiotti, S. Marcon, C. D'Agostino, G. Vaccari, M. Conte, et al. (2007)
J. Virol. 81, 4872-4876
 |  Abstract »  |  Full Text »  |  PDF »

Resistance to Chronic Wasting Disease in Transgenic Mice Expressing a Naturally Occurring Allelic Variant of Deer Prion Protein.

K. Meade-White, B. Race, M. Trifilo, A. Bossers, C. Favara, R. Lacasse, M. Miller, E. Williams, M. Oldstone, R. Race, et al. (2007)
J. Virol. 81, 4533-4539
 |  Abstract »  |  Full Text »  |  PDF »

Diversity in prion protein oligomerization pathways results from domain expansion as revealed by hydrogen/deuterium exchange and disulfide linkage.

F. Eghiaian, T. Daubenfeld, Y. Quenet, M. van Audenhaege, A.-P. Bouin, G. van der Rest, J. Grosclaude, and H. Rezaei (2007)
PNAS 104, 7414-7419
 |  Abstract »  |  Full Text »  |  PDF »

Human prion proteins with pathogenic mutations share common conformational changes resulting in enhanced binding to glycosaminoglycans.

S. Yin, N. Pham, S. Yu, C. Li, P. Wong, B. Chang, S.-C. Kang, E. Biasini, P. Tien, D. A. Harris, et al. (2007)
PNAS 104, 7546-7551
 |  Abstract »  |  Full Text »  |  PDF »

Polymorphisms of the prion protein gene coding region in born-after-the-reinforced-ban (BARB) bovine spongiform encephalopathy cattle in Great Britain.

G. C. Saunders, P. C. Griffiths, S. Cawthraw, A. C. Tout, P. Wiener, J. A. Woolliams, J. L. Williams, and O. Windl (2007)
J. Gen. Virol. 88, 1374-1378
 |  Abstract »  |  Full Text »  |  PDF »

Immunological differences between susceptible and resistant sheep during the preclinical phase of scrapie infection.

S. L. Eaton, M. Rocchi, L. Gonzalez, S. Hamilton, J. Finlayson, J. Sales, M. Jeffrey, P. J. Steele, M. P. Dagleish, S. M. Rodger, et al. (2007)
J. Gen. Virol. 88, 1384-1391
 |  Abstract »  |  Full Text »  |  PDF »

In Vitro Analysis of SpUre2p, a Prion-related Protein, Exemplifies the Relationship between Amyloid and Prion.

F. Immel, Y. Jiang, Y.-Q. Wang, C. Marchal, L. Maillet, S. Perrett, and C. Cullin (2007)
J. Biol. Chem. 282, 7912-7920
 |  Abstract »  |  Full Text »  |  PDF »

Oligomerization of the Human Prion Protein Proceeds via a Molten Globule Intermediate.

R. Gerber, A. Tahiri-Alaoui, P. J. Hore, and W. James (2007)
J. Biol. Chem. 282, 6300-6307
 |  Abstract »  |  Full Text »  |  PDF »

Dynamics and genetics of PrPSc placental accumulation in sheep.

C. Lacroux, F. Corbiere, G. Tabouret, S. Lugan, P. Costes, J. Mathey, J. M. Delmas, J. L. Weisbecker, G. Foucras, H. Cassard, et al. (2007)
J. Gen. Virol. 88, 1056-1061
 |  Abstract »  |  Full Text »  |  PDF »

Microglial Cell Line Established from Prion Protein-Overexpressing Mice Is Susceptible to Various Murine Prion Strains.

Y. Iwamaru, T. Takenouchi, K. Ogihara, M. Hoshino, M. Takata, M. Imamura, Y. Tagawa, H. Hayashi-Kato, Y. Ushiki-Kaku, Y. Shimizu, et al. (2007)
J. Virol. 81, 1524-1527
 |  Abstract »  |  Full Text »  |  PDF »

Importance of the Hsp70 ATPase Domain in Yeast Prion Propagation.

H. M. Loovers, E. Guinan, and G. W. Jones (2007)
Genetics 175, 621-630
 |  Abstract »  |  Full Text »  |  PDF »

beta-Sheet core of human prion protein amyloid fibrils as determined by hydrogen/deuterium exchange.

X. Lu, P. L. Wintrode, and W. K. Surewicz (2007)
PNAS 104, 1510-1515
 |  Abstract »  |  Full Text »  |  PDF »

Prion Interference Is Due to a Reduction in Strain-Specific PrPSc Levels.

J. C. Bartz, M. L. Kramer, M. H. Sheehan, J. A. L. Hutter, J. I. Ayers, R. A. Bessen, and A. E. Kincaid (2007)
J. Virol. 81, 689-697
 |  Abstract »  |  Full Text »  |  PDF »

Test for Detection of Disease-Associated Prion Aggregate in the Blood of Infected but Asymptomatic Animals.

B. Chang, X. Cheng, S. Yin, T. Pan, H. Zhang, P. Wong, S.-C. Kang, F. Xiao, H. Yan, C. Li, et al. (2007)
Clin. Vaccine Immunol. 14, 36-43
 |  Abstract »  |  Full Text »  |  PDF »

Prion infectivity in variant Creutzfeldt-Jakob disease rectum.

J D F Wadsworth, S Joiner, K Fox, J M Linehan, M Desbruslais, S Brandner, E A Asante, and J Collinge (2007)
Gut 56, 90-94
 |  Abstract »  |  Full Text »  |  PDF »

Strain Fidelity of Chronic Wasting Disease upon Murine Adaptation.

C. J. Sigurdson, G. Manco, P. Schwarz, P. Liberski, E. A. Hoover, S. Hornemann, M. Polymenidou, M. W. Miller, M. Glatzel, and A. Aguzzi (2006)
J. Virol. 80, 12303-12311
 |  Abstract »  |  Full Text »  |  PDF »

Transmission and characterization of bovine spongiform encephalopathy sources in two ovine transgenic mouse lines (TgOvPrP4 and TgOvPrP59).

C. Cordier, A. Bencsik, S. Philippe, D. Betemps, F. Ronzon, D. Calavas, C. Crozet, and T. Baron (2006)
J. Gen. Virol. 87, 3763-3771
 |  Abstract »  |  Full Text »  |  PDF »

Accelerated Accumulation of Misfolded Prion Protein and Spongiform Degeneration in a Drosophila Model of Gerstmann-Straussler-Scheinker Syndrome.

B. A. Gavin, M. J. Dolph, N. R. Deleault, J. C. Geoghegan, V. Khurana, M. B. Feany, P. J. Dolph, and S. Supattapone (2006)
J. Neurosci. 26, 12408-12414
 |  Abstract »  |  Full Text »  |  PDF »

Ultra-efficient Replication of Infectious Prions by Automated Protein Misfolding Cyclic Amplification.

P. Saa, J. Castilla, and C. Soto (2006)
J. Biol. Chem. 281, 35245-35252
 |  Abstract »  |  Full Text »  |  PDF »

Junctional expression of the prion protein PrPC by brain endothelial cells: a role in trans-endothelial migration of human monocytes.

P. Viegas, N. Chaverot, H. Enslen, N. Perriere, P.-O. Couraud, and S. Cazaubon (2006)
J. Cell Sci. 119, 4634-4643
 |  Abstract »  |  Full Text »  |  PDF »

Early and Rapid Engraftment of Bone Marrow-Derived Microglia in Scrapie..

J. Priller, M. Prinz, M. Heikenwalder, N. Zeller, P. Schwarz, F. L. Heppner, and A. Aguzzi (2006)
J. Neurosci. 26, 11753-11762
 |  Abstract »  |  Full Text »  |  PDF »

PrP genotypes of atypical scrapie cases in Great Britain..

G. C. Saunders, S. Cawthraw, S. J. Mountjoy, J. Hope, and O. Windl (2006)
J. Gen. Virol. 87, 3141-3149
 |  Abstract »  |  Full Text »  |  PDF »

Cell-free formation of misfolded prion protein with authentic prion infectivity.

P. Weber, A. Giese, N. Piening, G. Mitteregger, A. Thomzig, M. Beekes, and H. A. Kretzschmar (2006)
PNAS 103, 15818-15823
 |  Abstract »  |  Full Text »  |  PDF »

Prion diseases in humans: an update.

R. BUTLER (2006)
The British Journal of Psychiatry 189, 295-296
 |  Abstract »  |  Full Text »  |  PDF »

Pressure-Jump-Induced Kinetics Reveals a Hydration Dependent Folding/Unfolding Mechanism of Ribonuclease A.

J. Font, J. Torrent, M. Ribo, D. V. Laurents, C. Balny, M. Vilanova, and R. Lange (2006)
Biophys. J. 91, 2264-2274
 |  Abstract »  |  Full Text »  |  PDF »

A systematic review of prion therapeutics in experimental models.

C. R Trevitt and J. Collinge (2006)
Brain 129, 2241-2265
 |  Abstract »  |  Full Text »  |  PDF »

Codon 129 polymorphism of the human prion protein influences the kinetics of amyloid formation..

P. A. Lewis, M. H. Tattum, S. Jones, D. Bhelt, M. Batchelor, A. R. Clarke, J. Collinge, and G. S. Jackson (2006)
J. Gen. Virol. 87, 2443-2449
 |  Abstract »  |  Full Text »  |  PDF »

Cross-Talk between RNA and Prions.

C. G. Crist and Y. Nakamura (2006)
J. Biochem. 140, 167-173
 |  Abstract »  |  Full Text »  |  PDF »

Prion-induced amyloid heart disease with high blood infectivity in transgenic mice..

M. J. Trifilo, T. Yajima, Y. Gu, N. Dalton, K. L. Peterson, R. E. Race, K. Meade-White, J. L. Portis, E. Masliah, K. U. Knowlton, et al. (2006)
Science 313, 94-97
 |  Abstract »  |  Full Text »  |  PDF »

Childhood Onset in Familial Prion Disease With a Novel Mutation in the PRNP Gene..

E. Rogaeva, C. Zadikoff, J. Ponesse, G. Schmitt-Ulms, T. Kawarai, C. Sato, S. Salehi-Rad, P. St. George-Hyslop, and A. E. Lang (2006)
Arch Neurol 63, 1016-1021
 |  Abstract »  |  Full Text »  |  PDF »

Acid inactivation of prions: efficient at elevated temperature or high acid concentration..

T. R. Appel, R. Lucassen, M. H. Groschup, M. Joncic, M. Beekes, and D. Riesner (2006)
J. Gen. Virol. 87, 1385-1394
 |  Abstract »  |  Full Text »  |  PDF »

Prion Proteins with Insertion Mutations Have Altered N-terminal Conformation and Increased Ligand Binding Activity and Are More Susceptible to Oxidative Attack.

S. Yin, S. Yu, C. Li, P. Wong, B. Chang, F. Xiao, S.-C. Kang, H. Yan, G. Xiao, J. Grassi, et al. (2006)
J. Biol. Chem. 281, 10698-10705
 |  Abstract »  |  Full Text »  |  PDF »

Conversion Efficiency of Bank Vole Prion Protein in Vitro Is Determined by Residues 155 and 170, but Does Not Correlate with the High Susceptibility of Bank Voles to Sheep Scrapie in Vivo.

N. Piening, R. Nonno, M. Di Bari, S. Walter, O. Windl, U. Agrimi, H. A. Kretzschmar, and U. Bertsch (2006)
J. Biol. Chem. 281, 9373-9384
 |  Abstract »  |  Full Text »  |  PDF »

Functional disruption of the prion protein gene in cloned goats..

G. Yu, J. Chen, H. Yu, S. Liu, J. Chen, X. Xu, H. Sha, X. Zhang, G. Wu, S. Xu, et al. (2006)
J. Gen. Virol. 87, 1019-1027
 |  Abstract »  |  Full Text »  |  PDF »

Characterization and Application of a Novel RNA Aptamer against the Mouse Prion Protein..

S. Sekiya, K. Noda, F. Nishikawa, T. Yokoyama, P. K.R. Kumar, and S. Nishikawa (2006)
J. Biochem. 139, 383-390
 |  Abstract »  |  Full Text »  |  PDF »

Atypical prion protein in sheep brain collected during the British scrapie-surveillance programme.

S. J. Everest, L. Thorne, D. A. Barnicle, J. C. Edwards, H. Elliott, R. Jackman, and J. Hope (2006)
J. Gen. Virol. 87, 471-477
 |  Abstract »  |  Full Text »  |  PDF »

Inactivation of Prions by Acidic Sodium Dodecyl Sulfate.

D. Peretz, S. Supattapone, K. Giles, J. Vergara, Y. Freyman, P. Lessard, J. G. Safar, D. V. Glidden, C. McCulloch, H.-O. B. Nguyen, et al. (2006)
J. Virol. 80, 322-331
 |  Abstract »  |  Full Text »  |  PDF »

Potential Role of Soil in the Transmission of Prion Disease.

P. T. Schramm, C. J. Johnson, N. E. Mathews, D. McKenzie, J. M. Aiken, and J. A. Pedersen (2006)
Reviews in Mineralogy and Geochemistry 64, 135-152
 |  Full Text »  |  PDF »

Disease-related Prion Protein Forms Aggresomes in Neuronal Cells Leading to Caspase Activation and Apoptosis.

M. Kristiansen, M. J. Messenger, P.-C. Klohn, S. Brandner, J. D. F. Wadsworth, J. Collinge, and S. J. Tabrizi (2005)
J. Biol. Chem. 280, 38851-38861
 |  Abstract »  |  Full Text »  |  PDF »

A newly identified type of scrapie agent can naturally infect sheep with resistant PrP genotypes.

A. Le Dur, V. Beringue, O. Andreoletti, F. Reine, T. L. Lai, T. Baron, B. Bratberg, J.-L. Vilotte, P. Sarradin, S. L. Benestad, et al. (2005)
PNAS 102, 16031-16036
 |  Abstract »  |  Full Text »  |  PDF »

Neurochemical Insights.

C. Treiber (2005)
Sci. Aging Knowl. Environ. 2005, pe32
 |  Abstract »  |  Full Text »

Coincident Scrapie Infection and Nephritis Lead to Urinary Prion Excretion.

H. Seeger, M. Heikenwalder, N. Zeller, J. Kranich, P. Schwarz, A. Gaspert, B. Seifert, G. Miele, and A. Aguzzi (2005)
Science 310, 324-326
 |  Abstract »  |  Full Text »  |  PDF »

An Aggregation-Specific Enzyme-Linked Immunosorbent Assay: Detection of Conformational Differences between Recombinant PrP Protein Dimers and PrPSc Aggregates.

T. Pan, B. Chang, P. Wong, C. Li, R. Li, S.-C. Kang, J. D. Robinson, A. R. Thompsett, P. Tein, S. Yin, et al. (2005)
J. Virol. 79, 12355-12364
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin 4 and Interleukin 10 Levels Are Elevated in the Cerebrospinal Fluid of Patients With Creutzfeldt-Jakob Disease.

K. Stoeck, M. Bodemer, B. Ciesielczyk, B. Meissner, M. Bartl, U. Heinemann, and I. Zerr (2005)
Arch Neurol 62, 1591-1594
 |  Abstract »  |  Full Text »  |  PDF »

The [URE3] Prion Is Not Conserved Among Saccharomyces Species.

N. Talarek, L. Maillet, C. Cullin, and M. Aigle (2005)
Genetics 171, 23-34
 |  Abstract »  |  Full Text »  |  PDF »

Immunoquantitative PCR for Prion Protein Detection in Sporadic Creutzfeldt-Jakob Disease.

S. Gofflot, M. Deprez, B. el Moualij, A. Osman, J.-F. Thonnart, O. Hougrand, E. Heinen, and W. Zorzi (2005)
Clin. Chem. 51, 1605-1611
 |  Abstract »  |  Full Text »  |  PDF »

Search for a Prion-Specific Nucleic Acid.

J. G. Safar, K. Kellings, A. Serban, D. Groth, J. E. Cleaver, S. B. Prusiner, and D. Riesner (2005)
J. Virol. 79, 10796-10806
 |  Abstract »  |  Full Text »  |  PDF »

Influence of the N-terminal domain on the aggregation properties of the prion protein.

K. N. Frankenfield, E. T. Powers, and J. W. Kelly (2005)
Protein Sci. 14, 2154-2166
 |  Abstract »  |  Full Text »  |  PDF »

The prion gene is associated with human long-term memory.

A. Papassotiropoulos, M. A. Wollmer, A. Aguzzi, C. Hock, R. M. Nitsch, and D. J.-F. de Quervain (2005)
Hum. Mol. Genet. 14, 2241-2246
 |  Abstract »  |  Full Text »  |  PDF »

Protease-resistant Prion Protein Amplification Reconstituted with Partially Purified Substrates and Synthetic Polyanions.

N. R. Deleault, J. C. Geoghegan, K. Nishina, R. Kascsak, R. A. Williamson, and S. Supattapone (2005)
J. Biol. Chem. 280, 26873-26879
 |  Abstract »  |  Full Text »  |  PDF »

Molecular neurology of prion disease.

J Collinge (2005)
J. Neurol. Neurosurg. Psychiatry 76, 906-919
 |  Abstract »  |  Full Text »  |  PDF »

Paracrine Inhibition of Prion Propagation by Anti-PrP Single-Chain Fv Miniantibodies.

G. Donofrio, F. L. Heppner, M. Polymenidou, C. Musahl, and A. Aguzzi (2005)
J. Virol. 79, 8330-8338
 |  Abstract »  |  Full Text »  |  PDF »

Prion biology relevant to bovine spongiform encephalopathy.

J. Novakofski, M. S. Brewer, N. Mateus-Pinilla, J. Killefer, and R. H. McCusker (2005)
J Anim Sci 83, 1455-1476
 |  Abstract »  |  Full Text »  |  PDF »

Truncated Prion Protein and Doppel Are Myelinotoxic in the Absence of Oligodendrocytic PrPC.

I. Radovanovic, N. Braun, O. T. Giger, K. Mertz, G. Miele, M. Prinz, B. Navarro, and A. Aguzzi (2005)
J. Neurosci. 25, 4879-4888
 |  Abstract »  |  Full Text »  |  PDF »

Mapping PrPSc Propagation in Experimental and Natural Scrapie in Sheep with Different PrP Genotypes.

C. Ersdal, M. J. Ulvund, A. Espenes, S. L. Benestad, P. Sarradin, and T. Landsverk (2005)
Vet. Pathol. 42, 258-274
 |  Abstract »  |  Full Text »  |  PDF »

Synthetic prions generated in vitro are similar to a newly identified subpopulation of PrPSc from sporadic Creutzfeldt-Jakob Disease.

O. V. Bocharova, L. Breydo, V. V. Salnikov, A. C. Gill, and I. V. Baskakov (2005)
Protein Sci. 14, 1222-1232
 |  Abstract »  |  Full Text »  |  PDF »

Heparan Sulfate Is a Cellular Receptor for Purified Infectious Prions.

L. Horonchik, S. Tzaban, O. Ben-Zaken, Y. Yedidia, A. Rouvinski, D. Papy-Garcia, D. Barritault, I. Vlodavsky, and A. Taraboulos (2005)
J. Biol. Chem. 280, 17062-17067
 |  Abstract »  |  Full Text »  |  PDF »

A novel mutation (G114V) in the prion protein gene in a family with inherited prion disease.

M. -M. Rodriguez, K. Peoc'h, S. Haik, C. Bouchet, L. Vernengo, G. Manana, R. Salamano, L. Carrasco, M. Lenne, P. Beaudry, et al. (2005)
Neurology 64, 1455-1457
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Human Prion Diseases: Molecular and Clinical Aspects.

M. Glatzel, K. Stoeck, H. Seeger, T. Luhrs, and A. Aguzzi (2005)
Arch Neurol 62, 545-552
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Technical Note: Determination of alleles of the ovine PRNP gene using PCR-single-strand conformational polymorphism analysis.

H. Zhou, J. G. H. Hickford, and Q. Fang (2005)
J Anim Sci 83, 745-749
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Screening of 145 Anti-PrP Monoclonal Antibodies for Their Capacity to Inhibit PrPSc Replication in Infected Cells.

C. Feraudet, N. Morel, S. Simon, H. Volland, Y. Frobert, C. Creminon, D. Vilette, S. Lehmann, and J. Grassi (2005)
J. Biol. Chem. 280, 11247-11258
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Protein Conformation Significantly Influences Immune Responses to Prion Protein.

A. Khalili-Shirazi, S. Quaratino, M. Londei, L. Summers, M. Tayebi, A. R. Clarke, S. H. Hawke, G. S. Jackson, and J. Collinge (2005)
J. Immunol. 174, 3256-3263
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Kinetics of Fibril Formation by Polyalanine Peptides.

H. D. Nguyen and C. K. Hall (2005)
J. Biol. Chem. 280, 9074-9082
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Polymorphisms at codons 108 and 189 in murine PrP play distinct roles in the control of scrapie incubation time.

R. M. Barron, H. Baybutt, N. L. Tuzi, J. McCormack, D. King, R. C. Moore, D. W. Melton, and J. C. Manson (2005)
J. Gen. Virol. 86, 859-868
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An enzyme-detergent method for effective prion decontamination of surgical steel.

G. S. Jackson, E. McKintosh, E. Flechsig, K. Prodromidou, P. Hirsch, J. Linehan, S. Brandner, A. R. Clarke, C. Weissmann, and J. Collinge (2005)
J. Gen. Virol. 86, 869-878
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Novel Antibody-Lectin Enzyme-Linked Immunosorbent Assay That Distinguishes Prion Proteins in Sporadic and Variant Cases of Creutzfeldt-Jakob Disease.

T. Pan, R. Li, B.-S. Wong, S.-C. Kang, J. Ironside, and M.-S. Sy (2005)
J. Clin. Microbiol. 43, 1118-1126
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Chronic Lymphocytic Inflammation Specifies the Organ Tropism of Prions.

M. Heikenwalder, N. Zeller, H. Seeger, M. Prinz, P.-C. Klohn, P. Schwarz, N. H. Ruddle, C. Weissmann, and A. Aguzzi (2005)
Science 307, 1107-1110
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