Science 9 April 1982: Vol. 216. no. 4542, pp. 136 - 144 DOI: 10.1126/science.6801762

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Articles

Transmissions of variant Creutzfeldt-Jakob disease from brain and lymphoreticular tissue show uniform and conserved bovine spongiform encephalopathy-related phenotypic properties on primary and secondary passage in wild-type mice.

D. L. Ritchie, A. Boyle, I. McConnell, M. W. Head, J. W. Ironside, and M. E. Bruce (2009)
J. Gen. Virol. 90, 3075-3082
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Protective Prion Protein Variant that Colocalizes with Kuru Exposure.

S. Mead, J. Whitfield, M. Poulter, P. Shah, J. Uphill, T. Campbell, H. Al-Dujaily, H. Hummerich, J. Beck, C. A. Mein, et al. (2009)
N. Engl. J. Med. 361, 2056-2065
 |  Abstract »  |  Full Text »  |  PDF »

Prions: Protein Aggregation and Infectious Diseases.

A. Aguzzi and A. M. Calella (2009)
Physiol Rev 89, 1105-1152
 |  Abstract »  |  Full Text »  |  PDF »

Protective effect of the T112 PrP variant in sheep challenged with bovine spongiform encephalopathy.

G. C. Saunders, I. Lantier, S. Cawthraw, P. Berthon, S. J. Moore, M. E. Arnold, O. Windl, M. M. Simmons, O. Andreoletti, S. Bellworthy, et al. (2009)
J. Gen. Virol. 90, 2569-2574
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Structures of Scrapie Prion Protein (PrPSc)-seeded Versus Spontaneous Recombinant Prion Protein Fibrils Revealed by Hydrogen/Deuterium Exchange.

V. Smirnovas, J.-I. Kim, X. Lu, R. Atarashi, B. Caughey, and W. K. Surewicz (2009)
J. Biol. Chem. 284, 24233-24241
 |  Abstract »  |  Full Text »  |  PDF »

Measuring prions by bioluminescence imaging.

G. Tamguney, K. P. Francis, K. Giles, A. Lemus, S. J. DeArmond, and S. B. Prusiner (2009)
PNAS 106, 15002-15006
 |  Abstract »  |  Full Text »  |  PDF »

Conformational Properties of {beta}-PrP.

L. L. P. Hosszu, C. R. Trevitt, S. Jones, M. Batchelor, D. J. Scott, G. S. Jackson, J. Collinge, J. P. Waltho, and A. R. Clarke (2009)
J. Biol. Chem. 284, 21981-21990
 |  Abstract »  |  Full Text »  |  PDF »

Immunological mimicry of PrPC-PrPSc interactions: antibody-induced PrP misfolding.

L. Li, W. Guest, A. Huang, S. S. Plotkin, and N. R. Cashman (2009)
Protein Eng. Des. Sel. 22, 523-529
 |  Abstract »  |  Full Text »  |  PDF »

New Approach for M-Cell-Specific Molecules Screening by Comprehensive Transcriptome Analysis.

G. Nakato, S. Fukuda, K. Hase, R. Goitsuka, M. D. Cooper, and H. Ohno (2009)
DNA Res 16, 227-235
 |  Abstract »  |  Full Text »  |  PDF »

Alternative Translation Initiation Generates Cytoplasmic Sheep Prion Protein.

C. Lund, C. M. Olsen, S. Skogtvedt, H. Tveit, K. Prydz, and M. A. Tranulis (2009)
J. Biol. Chem. 284, 19668-19678
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of Prion Protein at Serine 43 Induces Prion Protein Conformational Change.

P. N. Giannopoulos, C. Robertson, J. Jodoin, H. Paudel, S. A. Booth, and A. C. LeBlanc (2009)
J. Neurosci. 29, 8743-8751
 |  Abstract »  |  Full Text »  |  PDF »

Prion Protein Glycosylation Is Not Required for Strain-Specific Neurotropism.

J. R. Piro, B. T. Harris, K. Nishina, C. Soto, R. Morales, J. R. Rees, and S. Supattapone (2009)
J. Virol. 83, 5321-5328
 |  Abstract »  |  Full Text »  |  PDF »

Detection of classical and atypical/Nor98 scrapie by the paraffin-embedded tissue blot method.

W. M. Wemheuer, S. L. Benestad, A. Wrede, W. E. Wemheuer, B. Brenig, B. Bratberg, and W. J. Schulz-Schaeffer (2009)
Vet Rec. 164, 677-681
 |  Abstract »  |  Full Text »  |  PDF »

Heterologous Stacking of Prion Protein Peptides Reveals Structural Details of Fibrils and Facilitates Complete Inhibition of Fibril Growth.

R. S. Boshuizen, V. Schulz, M. Morbin, G. Mazzoleni, R. H. Meloen, and J. P. M. Langedijk (2009)
J. Biol. Chem. 284, 12809-12820
 |  Abstract »  |  Full Text »  |  PDF »

Selfish prion of Rnq1 mutant in yeast.

H. Kurahashi, S. Shibata, M. Ishiwata, and Y. Nakamura (2009)
Genes Cells 14, 659-668
 |  Abstract »  |  Full Text »  |  PDF »

Olfactory System Involvement in Natural Scrapie Disease.

C. Corona, C. Porcario, F. Martucci, B. Iulini, B. Manea, M. Gallo, C. Palmitessa, C. Maurella, M. Mazza, M. Pezzolato, et al. (2009)
J. Virol. 83, 3657-3667
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Adjacent Binding Sites for the YY1 and E4BP4 Transcription Factors in the Ovine PrP (Prion) Gene Promoter.

S. T. G. Burgess, C. Shen, L. A. Ferguson, G. T. O'Neill, K. Docherty, N. Hunter, and W. Goldmann (2009)
J. Biol. Chem. 284, 6716-6724
 |  Abstract »  |  Full Text »  |  PDF »

Highly sensitive, quantitative cell-based assay for prions adsorbed to solid surfaces.

J. A. Edgeworth, G. S. Jackson, A. R. Clarke, C. Weissmann, and J. Collinge (2009)
PNAS 106, 3479-3483
 |  Abstract »  |  Full Text »  |  PDF »

Three serial passages of bovine spongiform encephalopathy in sheep do not significantly affect discriminatory test results.

M. Stack, L. Gonzalez, M. Jeffrey, S. Martin, C. Macaldowie, M. Chaplin, J. Thorne, R. Sayers, L. Davis, J. Bramwell, et al. (2009)
J. Gen. Virol. 90, 764-768
 |  Abstract »  |  Full Text »  |  PDF »

Prion Variants and Species Barriers Among Saccharomyces Ure2 Proteins.

H. K. Edskes, L. M. McCann, A. M. Hebert, and R. B. Wickner (2009)
Genetics 181, 1159-1167
 |  Abstract »  |  Full Text »  |  PDF »

Crystal structure of human prion protein bound to a therapeutic antibody.

S. V. Antonyuk, C. R. Trevitt, R. W. Strange, G. S. Jackson, D. Sangar, M. Batchelor, S. Cooper, C. Fraser, S. Jones, T. Georgiou, et al. (2009)
PNAS 106, 2554-2558
 |  Abstract »  |  Full Text »  |  PDF »

The NatA Acetyltransferase Couples Sup35 Prion Complexes to the [PSI+] Phenotype.

J. A. Pezza, S. X. Langseth, R. Raupp Yamamoto, S. M. Doris, S. P. Ulin, A. R. Salomon, and T. R. Serio (2009)
Mol. Biol. Cell 20, 1068-1080
 |  Abstract »  |  Full Text »  |  PDF »

A G-protein {gamma} subunit mimic is a general antagonist of prion propagation in Saccharomyces cerevisiae.

M. Ishiwata, H. Kurahashi, and Y. Nakamura (2009)
PNAS 106, 791-796
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Prion Gene Expression by Transcription Factors SP1 and Metal Transcription Factor-1.

S. A. Bellingham, L. A. Coleman, C. L. Masters, J. Camakaris, and A. F. Hill (2009)
J. Biol. Chem. 284, 1291-1301
 |  Abstract »  |  Full Text »  |  PDF »

De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis.

C. J. Sigurdson, K. P. R. Nilsson, S. Hornemann, M. Heikenwalder, G. Manco, P. Schwarz, D. Ott, T. Rulicke, P. P. Liberski, C. Julius, et al. (2009)
PNAS 106, 304-309
 |  Abstract »  |  Full Text »  |  PDF »

Prion Strain Targeting Independent of Strain-Specific Neuronal Tropism.

J. I. Ayers, A. E. Kincaid, and J. C. Bartz (2009)
J. Virol. 83, 81-87
 |  Abstract »  |  Full Text »  |  PDF »

Prion Protein Amyloid Formation under Native-like Conditions Involves Refolding of the C-terminal {alpha}-Helical Domain.

N. J. Cobb, A. C. Apetri, and W. K. Surewicz (2008)
J. Biol. Chem. 283, 34704-34711
 |  Abstract »  |  Full Text »  |  PDF »

Identifying Key Components of the PrPC-PrPSc Replicative Interface.

G. C. Abalos, J. T. Cruite, A. Bellon, S. Hemmers, J. Akagi, J. A. Mastrianni, R. A. Williamson, and L. Solforosi (2008)
J. Biol. Chem. 283, 34021-34028
 |  Abstract »  |  Full Text »  |  PDF »

Association of a null allele of SPRN with variant Creutzfeldt-Jakob disease.

J A Beck, T A Campbell, G Adamson, M Poulter, J B Uphill, E Molou, J Collinge, and S Mead (2008)
J. Med. Genet. 45, 813-817
 |  Abstract »  |  Full Text »  |  PDF »

The changing face of kuru: a personal perspective.

J. D Mathews (2008)
Phil Trans R Soc B 363, 3679-3684
 |  Abstract »  |  Full Text »  |  PDF »

Lessons of kuru research: background to recent studies with some personal reflections.

J. Collinge (2008)
Phil Trans R Soc B 363, 3689-3696
 |  Abstract »  |  Full Text »  |  PDF »

The epidemiology of kuru: monitoring the epidemic from its peak to its end.

M. P Alpers (2008)
Phil Trans R Soc B 363, 3707-3713
 |  Abstract »  |  Full Text »  |  PDF »

A clinical study of kuru patients with long incubation periods at the end of the epidemic in Papua New Guinea.

J. Collinge, J. Whitfield, E. McKintosh, A. Frosh, S. Mead, A. F Hill, S. Brandner, D. Thomas, and M. P Alpers (2008)
Phil Trans R Soc B 363, 3725-3739
 |  Abstract »  |  Full Text »  |  PDF »

The origin of the prion agent of kuru: molecular and biological strain typing.

J. D.F Wadsworth, S. Joiner, J. M Linehan, E. A Asante, S. Brandner, and J. Collinge (2008)
Phil Trans R Soc B 363, 3747-3753
 |  Abstract »  |  Full Text »  |  PDF »

Central and peripheral pathology of kuru: pathological analysis of a recent case and comparison with other forms of human prion disease.

S. Brandner, J. Whitfield, K. Boone, A. Puwa, C. O'Malley, J. M Linehan, S. Joiner, F. Scaravilli, I. Calder, M. P. Alpers, et al. (2008)
Phil Trans R Soc B 363, 3755-3763
 |  Abstract »  |  Full Text »  |  PDF »

Molecular and Transmission Characteristics of Primary-Passaged Ovine Scrapie Isolates in Conventional and Ovine PrP Transgenic Mice.

A. M. Thackray, L. Hopkins, J. Spiropoulos, and R. Bujdoso (2008)
J. Virol. 82, 11197-11207
 |  Abstract »  |  Full Text »  |  PDF »

Small-Ruminant Lentivirus Enhances PrPSc Accumulation in Cultured Sheep Microglial Cells.

J. B. Stanton, D. P. Knowles, K. I. O'Rourke, L. M. Herrmann-Hoesing, B. A. Mathison, and T. V. Baszler (2008)
J. Virol. 82, 9839-9847
 |  Abstract »  |  Full Text »  |  PDF »

The effects of prion protein proteolysis and disaggregation on the strain properties of hamster scrapie.

A. M. Deleault, N. R. Deleault, B. T. Harris, J. R. Rees, and S. Supattapone (2008)
J. Gen. Virol. 89, 2642-2650
 |  Abstract »  |  Full Text »  |  PDF »

A collaborative Canadian-United Kingdom evaluation of an immunohistochemistry protocol to diagnose bovine spongiform encephalopathy.

L. Manning, K. I. O'Rourke, D. P. Knowles, S. A. Marsh, Y. I. Spencer, E. Moffat, G. A.H. Wells, and S. Czub (2008)
J Vet Diagn Invest 20, 504-508
 |  Abstract »  |  Full Text »  |  PDF »

A Regulatory Role of the Rnq1 Nonprion Domain for Prion Propagation and Polyglutamine Aggregates.

H. Kurahashi, M. Ishiwata, S. Shibata, and Y. Nakamura (2008)
Mol. Cell. Biol. 28, 3313-3323
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid Fibrils of the HET-s(218-289) Prion Form a {beta} Solenoid with a Triangular Hydrophobic Core.

C. Wasmer, A. Lange, H. Van Melckebeke, A. B. Siemer, R. Riek, and B. H. Meier (2008)
Science 319, 1523-1526
 |  Abstract »  |  Full Text »  |  PDF »

The elk PRNP codon 132 polymorphism controls cervid and scrapie prion propagation.

K. M. Green, S. R. Browning, T. S. Seward, J. E. Jewell, D. L. Ross, M. A. Green, E. S. Williams, E. A. Hoover, and G. C. Telling (2008)
J. Gen. Virol. 89, 598-608
 |  Abstract »  |  Full Text »  |  PDF »

Protein Misfolding and Neurodegeneration.

C. Soto and L. D. Estrada (2008)
Arch Neurol 65, 184-189
 |  Abstract »  |  Full Text »  |  PDF »

Unraveling prion strains with cell biology and organic chemistry.

A. Aguzzi (2008)
PNAS 105, 11-12
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Decontamination of surgical instruments from prions. II. In vivo findings with a model system for testing the removal of scrapie infectivity from steel surfaces.

K. Lemmer, M. Mielke, C. Kratzel, M. Joncic, M. Oezel, G. Pauli, and M. Beekes (2008)
J. Gen. Virol. 89, 348-358
 |  Abstract »  |  Full Text »  |  PDF »

Selective Incorporation of Polyanionic Molecules into Hamster Prions.

J. C. Geoghegan, P. A. Valdes, N. R. Orem, N. R. Deleault, R. A. Williamson, B. T. Harris, and S. Supattapone (2007)
J. Biol. Chem. 282, 36341-36353
 |  Abstract »  |  Full Text »  |  PDF »

Influence of Water, Fat, and Glycerol on the Mechanism of Thermal Prion Inactivation.

H. Muller, L. Stitz, H. Wille, S. B. Prusiner, and D. Riesner (2007)
J. Biol. Chem. 282, 35855-35867
 |  Abstract »  |  Full Text »  |  PDF »

High Titers of Transmissible Spongiform Encephalopathy Infectivity Associated with Extremely Low Levels of PrPSc in Vivo.

R. M. Barron, S. L. Campbell, D. King, A. Bellon, K. E. Chapman, R. A. Williamson, and J. C. Manson (2007)
J. Biol. Chem. 282, 35878-35886
 |  Abstract »  |  Full Text »  |  PDF »

Medical Mineralogy and Geochemistry: An Interfacial Science.

N. Sahai (2007)
Elements 3, 381-384
 |  Abstract »  |  Full Text »  |  PDF »

Role of Hsp104 in the Propagation and Inheritance of the [Het-s] Prion.

L. Malato, S. Dos Reis, L. Benkemoun, R. Sabate, and S. J. Saupe (2007)
Mol. Biol. Cell 18, 4803-4812
 |  Abstract »  |  Full Text »  |  PDF »

Molecular architecture of human prion protein amyloid: A parallel, in-register -structure.

N. J. Cobb, F. D. Sonnichsen, H. Mchaourab, and W. K. Surewicz (2007)
PNAS 104, 18946-18951
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Characterization of the Rocky Mountain Elk (Cervus elaphus nelsoni) PRNP Putative Promoter.

C. M. Seabury, C. A. Gill, J. W. Templeton, J. B. Dyar, J. N. Derr, D. L. Adelson, E. Owens, D. S. Davis, D. C. Kraemer, and J. E. Womack (2007)
J. Hered.
 |  Abstract »  |  Full Text »  |  PDF »

Mouse-Adapted Ovine Scrapie Prion Strains Are Characterized by Different Conformers of PrPSc.

A. M. Thackray, L. Hopkins, M. A. Klein, and R. Bujdoso (2007)
J. Virol. 81, 12119-12127
 |  Abstract »  |  Full Text »  |  PDF »

A General Model of Prion Strains and Their Pathogenicity.

J. Collinge and A. R. Clarke (2007)
Science 318, 930-936
 |  Abstract »  |  Full Text »  |  PDF »

PrPc Does Not Mediate Internalization of PrPSc but Is Required at an Early Stage for De Novo Prion Infection of Rov Cells.

S. Paquet, N. Daude, M.-P. Courageot, J. Chapuis, H. Laude, and D. Vilette (2007)
J. Virol. 81, 10786-10791
 |  Abstract »  |  Full Text »  |  PDF »

Polylactide-Coglycolide Microspheres CoEncapsulating Recombinant Tandem Prion Protein with CpG-Oligonucleotide Break Self-Tolerance to Prion Protein in Wild-Type Mice and Induce CD4 and CD8 T Cell Responses.

G. Kaiser-Schulz, A. Heit, L. Quintanilla-Martinez, F. Hammerschmidt, S. Hess, L. Jennen, H. Rezaei, H. Wagner, and H. M. Schatzl (2007)
J. Immunol. 179, 2797-2807
 |  Abstract »  |  Full Text »  |  PDF »

Species-specific Differences in the Intermediate States of Human and Syrian Hamster Prion Protein Detected by High Pressure NMR Spectroscopy.

W. Kremer, N. Kachel, K. Kuwata, K. Akasaka, and H. R. Kalbitzer (2007)
J. Biol. Chem. 282, 22689-22698
 |  Abstract »  |  Full Text »  |  PDF »

Hot spots in prion protein for pathogenic conversion.

K. Kuwata, N. Nishida, T. Matsumoto, Y. O. Kamatari, J. Hosokawa-Muto, K. Kodama, H. K. Nakamura, K. Kimura, M. Kawasaki, Y. Takakura, et al. (2007)
PNAS 104, 11921-11926
 |  Abstract »  |  Full Text »  |  PDF »

From the Cover: Formation of native prions from minimal components in vitro.

N. R. Deleault, B. T. Harris, J. R. Rees, and S. Supattapone (2007)
PNAS 104, 9741-9746
 |  Abstract »  |  Full Text »  |  PDF »

PrPSc in Salivary Glands of Scrapie-Affected Sheep.

M. Vascellari, R. Nonno, F. Mutinelli, M. Bigolaro, M. A. Di Bari, E. Melchiotti, S. Marcon, C. D'Agostino, G. Vaccari, M. Conte, et al. (2007)
J. Virol. 81, 4872-4876
 |  Abstract »  |  Full Text »  |  PDF »

Resistance to Chronic Wasting Disease in Transgenic Mice Expressing a Naturally Occurring Allelic Variant of Deer Prion Protein.

K. Meade-White, B. Race, M. Trifilo, A. Bossers, C. Favara, R. Lacasse, M. Miller, E. Williams, M. Oldstone, R. Race, et al. (2007)
J. Virol. 81, 4533-4539
 |  Abstract »  |  Full Text »  |  PDF »

Diversity in prion protein oligomerization pathways results from domain expansion as revealed by hydrogen/deuterium exchange and disulfide linkage.

F. Eghiaian, T. Daubenfeld, Y. Quenet, M. van Audenhaege, A.-P. Bouin, G. van der Rest, J. Grosclaude, and H. Rezaei (2007)
PNAS 104, 7414-7419
 |  Abstract »  |  Full Text »  |  PDF »

Human prion proteins with pathogenic mutations share common conformational changes resulting in enhanced binding to glycosaminoglycans.

S. Yin, N. Pham, S. Yu, C. Li, P. Wong, B. Chang, S.-C. Kang, E. Biasini, P. Tien, D. A. Harris, et al. (2007)
PNAS 104, 7546-7551
 |  Abstract »  |  Full Text »  |  PDF »

Polymorphisms of the prion protein gene coding region in born-after-the-reinforced-ban (BARB) bovine spongiform encephalopathy cattle in Great Britain.

G. C. Saunders, P. C. Griffiths, S. Cawthraw, A. C. Tout, P. Wiener, J. A. Woolliams, J. L. Williams, and O. Windl (2007)
J. Gen. Virol. 88, 1374-1378
 |  Abstract »  |  Full Text »  |  PDF »

Immunological differences between susceptible and resistant sheep during the preclinical phase of scrapie infection.

S. L. Eaton, M. Rocchi, L. Gonzalez, S. Hamilton, J. Finlayson, J. Sales, M. Jeffrey, P. J. Steele, M. P. Dagleish, S. M. Rodger, et al. (2007)
J. Gen. Virol. 88, 1384-1391
 |  Abstract »  |  Full Text »  |  PDF »

In Vitro Analysis of SpUre2p, a Prion-related Protein, Exemplifies the Relationship between Amyloid and Prion.

F. Immel, Y. Jiang, Y.-Q. Wang, C. Marchal, L. Maillet, S. Perrett, and C. Cullin (2007)
J. Biol. Chem. 282, 7912-7920
 |  Abstract »  |  Full Text »  |  PDF »

Oligomerization of the Human Prion Protein Proceeds via a Molten Globule Intermediate.

R. Gerber, A. Tahiri-Alaoui, P. J. Hore, and W. James (2007)
J. Biol. Chem. 282, 6300-6307
 |  Abstract »  |  Full Text »  |  PDF »

Dynamics and genetics of PrPSc placental accumulation in sheep.

C. Lacroux, F. Corbiere, G. Tabouret, S. Lugan, P. Costes, J. Mathey, J. M. Delmas, J. L. Weisbecker, G. Foucras, H. Cassard, et al. (2007)
J. Gen. Virol. 88, 1056-1061
 |  Abstract »  |  Full Text »  |  PDF »

Microglial Cell Line Established from Prion Protein-Overexpressing Mice Is Susceptible to Various Murine Prion Strains.

Y. Iwamaru, T. Takenouchi, K. Ogihara, M. Hoshino, M. Takata, M. Imamura, Y. Tagawa, H. Hayashi-Kato, Y. Ushiki-Kaku, Y. Shimizu, et al. (2007)
J. Virol. 81, 1524-1527
 |  Abstract »  |  Full Text »  |  PDF »

Importance of the Hsp70 ATPase Domain in Yeast Prion Propagation.

H. M. Loovers, E. Guinan, and G. W. Jones (2007)
Genetics 175, 621-630
 |  Abstract »  |  Full Text »  |  PDF »

beta-Sheet core of human prion protein amyloid fibrils as determined by hydrogen/deuterium exchange.

X. Lu, P. L. Wintrode, and W. K. Surewicz (2007)
PNAS 104, 1510-1515
 |  Abstract »  |  Full Text »  |  PDF »

Prion Interference Is Due to a Reduction in Strain-Specific PrPSc Levels.

J. C. Bartz, M. L. Kramer, M. H. Sheehan, J. A. L. Hutter, J. I. Ayers, R. A. Bessen, and A. E. Kincaid (2007)
J. Virol. 81, 689-697
 |  Abstract »  |  Full Text »  |  PDF »

Test for Detection of Disease-Associated Prion Aggregate in the Blood of Infected but Asymptomatic Animals.

B. Chang, X. Cheng, S. Yin, T. Pan, H. Zhang, P. Wong, S.-C. Kang, F. Xiao, H. Yan, C. Li, et al. (2007)
Clin. Vaccine Immunol. 14, 36-43
 |  Abstract »  |  Full Text »  |  PDF »

Prion infectivity in variant Creutzfeldt-Jakob disease rectum.

J D F Wadsworth, S Joiner, K Fox, J M Linehan, M Desbruslais, S Brandner, E A Asante, and J Collinge (2007)
Gut 56, 90-94
 |  Abstract »  |  Full Text »  |  PDF »

Strain Fidelity of Chronic Wasting Disease upon Murine Adaptation.

C. J. Sigurdson, G. Manco, P. Schwarz, P. Liberski, E. A. Hoover, S. Hornemann, M. Polymenidou, M. W. Miller, M. Glatzel, and A. Aguzzi (2006)
J. Virol. 80, 12303-12311
 |  Abstract »  |  Full Text »  |  PDF »

Transmission and characterization of bovine spongiform encephalopathy sources in two ovine transgenic mouse lines (TgOvPrP4 and TgOvPrP59).

C. Cordier, A. Bencsik, S. Philippe, D. Betemps, F. Ronzon, D. Calavas, C. Crozet, and T. Baron (2006)
J. Gen. Virol. 87, 3763-3771
 |  Abstract »  |  Full Text »  |  PDF »

Accelerated Accumulation of Misfolded Prion Protein and Spongiform Degeneration in a Drosophila Model of Gerstmann-Straussler-Scheinker Syndrome.

B. A. Gavin, M. J. Dolph, N. R. Deleault, J. C. Geoghegan, V. Khurana, M. B. Feany, P. J. Dolph, and S. Supattapone (2006)
J. Neurosci. 26, 12408-12414
 |  Abstract »  |  Full Text »  |  PDF »

Ultra-efficient Replication of Infectious Prions by Automated Protein Misfolding Cyclic Amplification.

P. Saa, J. Castilla, and C. Soto (2006)
J. Biol. Chem. 281, 35245-35252
 |  Abstract »  |  Full Text »  |  PDF »

Junctional expression of the prion protein PrPC by brain endothelial cells: a role in trans-endothelial migration of human monocytes.

P. Viegas, N. Chaverot, H. Enslen, N. Perriere, P.-O. Couraud, and S. Cazaubon (2006)
J. Cell Sci. 119, 4634-4643
 |  Abstract »  |  Full Text »  |  PDF »

Early and Rapid Engraftment of Bone Marrow-Derived Microglia in Scrapie..

J. Priller, M. Prinz, M. Heikenwalder, N. Zeller, P. Schwarz, F. L. Heppner, and A. Aguzzi (2006)
J. Neurosci. 26, 11753-11762
 |  Abstract »  |  Full Text »  |  PDF »

PrP genotypes of atypical scrapie cases in Great Britain..

G. C. Saunders, S. Cawthraw, S. J. Mountjoy, J. Hope, and O. Windl (2006)
J. Gen. Virol. 87, 3141-3149
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Cell-free formation of misfolded prion protein with authentic prion infectivity.

P. Weber, A. Giese, N. Piening, G. Mitteregger, A. Thomzig, M. Beekes, and H. A. Kretzschmar (2006)
PNAS 103, 15818-15823
 |  Abstract »  |  Full Text »  |  PDF »

Prion diseases in humans: an update.

R. BUTLER (2006)
The British Journal of Psychiatry 189, 295-296
 |  Abstract »  |  Full Text »  |  PDF »

A systematic review of prion therapeutics in experimental models.

C. R Trevitt and J. Collinge (2006)
Brain 129, 2241-2265
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Codon 129 polymorphism of the human prion protein influences the kinetics of amyloid formation..

P. A. Lewis, M. H. Tattum, S. Jones, D. Bhelt, M. Batchelor, A. R. Clarke, J. Collinge, and G. S. Jackson (2006)
J. Gen. Virol. 87, 2443-2449
 |  Abstract »  |  Full Text »  |  PDF »

Cross-Talk between RNA and Prions.

C. G. Crist and Y. Nakamura (2006)
J. Biochem. 140, 167-173
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Prion-induced amyloid heart disease with high blood infectivity in transgenic mice..

M. J. Trifilo, T. Yajima, Y. Gu, N. Dalton, K. L. Peterson, R. E. Race, K. Meade-White, J. L. Portis, E. Masliah, K. U. Knowlton, et al. (2006)
Science 313, 94-97
 |  Abstract »  |  Full Text »  |  PDF »

Childhood Onset in Familial Prion Disease With a Novel Mutation in the PRNP Gene..

E. Rogaeva, C. Zadikoff, J. Ponesse, G. Schmitt-Ulms, T. Kawarai, C. Sato, S. Salehi-Rad, P. St. George-Hyslop, and A. E. Lang (2006)
Arch Neurol 63, 1016-1021
 |  Abstract »  |  Full Text »  |  PDF »

Acid inactivation of prions: efficient at elevated temperature or high acid concentration..

T. R. Appel, R. Lucassen, M. H. Groschup, M. Joncic, M. Beekes, and D. Riesner (2006)
J. Gen. Virol. 87, 1385-1394
 |  Abstract »  |  Full Text »  |  PDF »

Prion Proteins with Insertion Mutations Have Altered N-terminal Conformation and Increased Ligand Binding Activity and Are More Susceptible to Oxidative Attack.

S. Yin, S. Yu, C. Li, P. Wong, B. Chang, F. Xiao, S.-C. Kang, H. Yan, G. Xiao, J. Grassi, et al. (2006)
J. Biol. Chem. 281, 10698-10705
 |  Abstract »  |  Full Text »  |  PDF »

Conversion Efficiency of Bank Vole Prion Protein in Vitro Is Determined by Residues 155 and 170, but Does Not Correlate with the High Susceptibility of Bank Voles to Sheep Scrapie in Vivo.

N. Piening, R. Nonno, M. Di Bari, S. Walter, O. Windl, U. Agrimi, H. A. Kretzschmar, and U. Bertsch (2006)
J. Biol. Chem. 281, 9373-9384
 |  Abstract »  |  Full Text »  |  PDF »

Functional disruption of the prion protein gene in cloned goats..

G. Yu, J. Chen, H. Yu, S. Liu, J. Chen, X. Xu, H. Sha, X. Zhang, G. Wu, S. Xu, et al. (2006)
J. Gen. Virol. 87, 1019-1027
 |  Abstract »  |  Full Text »  |  PDF »

Characterization and Application of a Novel RNA Aptamer against the Mouse Prion Protein..

S. Sekiya, K. Noda, F. Nishikawa, T. Yokoyama, P. K.R. Kumar, and S. Nishikawa (2006)
J. Biochem. 139, 383-390
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Atypical prion protein in sheep brain collected during the British scrapie-surveillance programme.

S. J. Everest, L. Thorne, D. A. Barnicle, J. C. Edwards, H. Elliott, R. Jackman, and J. Hope (2006)
J. Gen. Virol. 87, 471-477
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Inactivation of Prions by Acidic Sodium Dodecyl Sulfate.

D. Peretz, S. Supattapone, K. Giles, J. Vergara, Y. Freyman, P. Lessard, J. G. Safar, D. V. Glidden, C. McCulloch, H.-O. B. Nguyen, et al. (2006)
J. Virol. 80, 322-331
 |  Abstract »  |  Full Text »  |  PDF »

Potential Role of Soil in the Transmission of Prion Disease.

P. T. Schramm, C. J. Johnson, N. E. Mathews, D. McKenzie, J. M. Aiken, and J. A. Pedersen (2006)
Reviews in Mineralogy and Geochemistry 64, 135-152
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Disease-related Prion Protein Forms Aggresomes in Neuronal Cells Leading to Caspase Activation and Apoptosis.

M. Kristiansen, M. J. Messenger, P.-C. Klohn, S. Brandner, J. D. F. Wadsworth, J. Collinge, and S. J. Tabrizi (2005)
J. Biol. Chem. 280, 38851-38861
 |  Abstract »  |  Full Text »  |  PDF »

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