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Science 2 April 1982:
Vol. 216. no. 4541, pp. 75 - 77
DOI: 10.1126/science.6950518
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Articles

Science, Vol 216, Issue 4541, 75-77
Copyright © 1982 by American Association for the Advancement of Science

articles

Ornithine decarboxylase: essential in proliferation but not differentiation of human promyelocytic leukemia cells

GD Luk, CI Civin, RM Weissman, and SB Baylin

The ornithine decarboxylase inhibitor DL-alpha-difluoromethyl ornithine inhibited a proliferation-associated increase in ornithine decarboxylase activity in cultured human promyelocytic leukemia cells, resulting in a marked suppression of cell proliferation and subsequent cell loss. It also inhibited increases in ornithine decarboxylase activity associated with the phorbol ester-induced conversion of promyelocytic HL-60 cells to monocyte-like cells and the retinoic acid-induced conversion to granulocyte-like cells. However, the inhibition of ornithine decarboxylase activity did not prevent cellular differentiation. These results suggest that polyamine biosynthesis has a specific role in cell proliferation rather than in inducing differentiation that is not accompanied by proliferation. The data also demonstrate that cessation of proliferation in HL-60 cells is not necessarily associated with differentiation.


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