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Science 2 April 1982:
Vol. 216. no. 4541, pp. 68 - 70
DOI: 10.1126/science.7063874
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Articles

Science, Vol 216, Issue 4541, 68-70
Copyright © 1982 by American Association for the Advancement of Science

articles

Cyclic biological expression in mouse mammary tumors

DT Kiang, M King, HJ Zhang, BJ Kennedy, and N Wang

Biological characteristics were assessed in GR mouse mammary tumors during 22 serial transplantations. Although unidirectional progression from hormone dependency to independency was observed, other biological markers such as progesterone receptors, polyploid frequency and thymidine kinase activity demonstrated cyclic phenomena every fourth to sixth transplant generation, suggesting the continued presence of regulatory mechanisms among various cells subpopulations.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cyclic AMP modifies the cellular distribution of connexin43 and induces a persistent increase in the junctional permeability of mouse mammary tumor cells.
M. Atkinson, P. Lampe, H. Lin, R Kollander, X. Li, and D. Kiang (1995)
J. Cell Sci. 108, 3079-3090
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Science. ISSN 0036-8075 (print), 1095-9203 (online)