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Science 2 April 1982:
Vol. 216. no. 4541, pp. 61 - 63
DOI: 10.1126/science.7063871
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Articles

Science, Vol 216, Issue 4541, 61-63
Copyright © 1982 by American Association for the Advancement of Science

articles

Developmental changes in the biliary excretion of methylmercury and glutathione

N Ballatori and TW Clarkson

The long half-time for methylmercury in the neonatal rats is explained by the neonatal liver's inability to secrete the toxin into bile, which in adults is the main route of elimination. The ability to secrete mercury into bile develops between 2 and 4 weeks of age and is correlated with the increasing ability of the developing liver to secrete glutathione into bile.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Comparative Proteomics of Excretory-Secretory Proteins Released by the Liver Fluke Fasciola hepatica in Sheep Host Bile and during in Vitro Culture ex Host.
R. M. Morphew, H. A. Wright, E. J. LaCourse, D. J. Woods, and P. M. Brophy (2007)
Mol. Cell. Proteomics 6, 963-972
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Differences Between Children and Adults: Implications for Risk Assessment at California EPA.
M. D. Miller, M. A. Marty, A. Arcus, J. Brown, D. Morry, and M. Sandy (2002)
International Journal of Toxicology 21, 403-418
   Abstract »    PDF »
Organic mercury compounds: human exposure and its relevance to public health.
J. F Risher, H E. Murray, and G. R Prince (2002)
Toxicology and Industrial Health 18, 109-160
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ATP-dependent Transport of Reduced Glutathione on YCF1, the Yeast Orthologue of Mammalian Multidrug Resistance Associated Proteins.
J. F. Rebbeor, G. C. Connolly, M. E. Dumont, and N. Ballatori (1998)
J. Biol. Chem. 273, 33449-33454
   Abstract »    Full Text »    PDF »


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