Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 26 March 1982:
Vol. 215. no. 4540, pp. 1643 - 1645
DOI: 10.1126/science.6280276
Prev | Table of Contents

Articles

Science, Vol 215, Issue 4540, 1643-1645
Copyright © 1982 by American Association for the Advancement of Science

articles

Spinal sympathetic neurons: possible sites of opiate-withdrawal suppression by clonidine

DN Franz, DB Hare, and KL McCloskey

Morphine, methadone, meperidine, fentanyl, and clonidine rapidly depressed transmission through sympathetic preganglionic neurons in cats with the spinal cord transected. Naloxone promptly antagonized this effect of the opiates but not that of clonidine which was reversed by alpha 2-adrenergic receptor antagonists. The independent depression of preganglionic neurons by clonidine may contribute to the ability of this drug to depress the symptoms of opiate withdrawal that are characterized by sympathetic hyperactivity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
{alpha}2-Receptor Agonists for Treatment and Prevention of Iatrogenic Opioid Abstinence Syndrome in Critically Ill Patients.
B. L Honey, R. J Benefield, J. L Miller, and P. N Johnson (2009)
Ann. Pharmacother. 43, 1506-1511
   Abstract »    Full Text »    PDF »
Activation of Coeruleospinal Noradrenergic Inhibitory Controls during Withdrawal from Morphine in the Rat.
D. S. Rohde and A. I. Basbaum (1998)
J. Neurosci. 18, 4393-4402
   Abstract »    Full Text »    PDF »
Clonidine Prophylaxis for Narcotic and Sedative Withdrawal Syndrome Following Laryngotracheal Reconstruction.
E. S. Deutsch and V. M. Nadkarni (1996)
Arch Otolaryngol Head Neck Surg 122, 1234-1238
   Abstract »    PDF »
Spinal sympathetic pathway: an enkephalin ladder.
M. Romagnano and R. Hamill (1984)
Science 225, 737-739
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)