Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 26 March 1982:
Vol. 215. no. 4540, pp. 1633 - 1635
DOI: 10.1126/science.6280275
Prev | Table of Contents | Next

Articles

Science, Vol 215, Issue 4540, 1633-1635
Copyright © 1982 by American Association for the Advancement of Science

articles

Solubilized adenosine receptors in the brain: regulation of guanine nucleotides

M Gavish, RR Goodman, and SH Snyder

Adenosine receptors associated with a reduction of adenylate cyclase and labeled by tritium-labeled cyclohexyladenosine can be solubilized from brain membranes with sodium cholate. Regulation of receptor binding by guanine nucleotides is retained in the soluble state. Influences of cations observed in membrane preparations of adenosine receptors are no longer detected with the solubilized receptors. The apparent retention of a complex of receptors and guanosine triphosphate binding but not cation binding protein in the soluble state may permit a molecular analysis of receptor regulation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Drug and neurotransmitter receptors in the brain.
S. Snyder (1984)
Science 224, 22-31
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)