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Science 26 March 1982: Vol. 215. no. 4540, pp. 1577 - 1585 DOI: 10.1126/science.7041255
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Articles
Science, Vol 215, Issue 4540, 1577-1585
Copyright © 1982 by American Association for the Advancement of Science
Rapid evolution of RNA genomes
J Holland,
K Spindler,
F Horodyski,
E Grabau,
S Nichol,
and
S VandePol
RNA viruses show high mutation frequencies partly because of a lack of the proofreading enzymes that assure fidelity of DNA replication. This high mutation frequency is coupled with high rates of replication reflected in rates of RNA genome evolution which can be more than a millionfold greater than the rates of the DNA chromosome evolution of their hosts. There are some disease implications for the DNA-based biosphere of this rapidly evolving RNA biosphere.
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