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Science 19 March 1982:
Vol. 215. no. 4539, pp. 1530 - 1532
DOI: 10.1126/science.7063862
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Articles

Science, Vol 215, Issue 4539, 1530-1532
Copyright © 1982 by American Association for the Advancement of Science

articles

Corticosterone: a critical factor in an opioid form of stress-induced analgesia

AJ MacLennan, RC Drugan, RL Hyson, SF Maier, J Madden 4th, and JD Barchas

The finding that some opioid-mediated forms of stress-induced analgesia are antagonized by hypophysectomy and dexamethasone has led to the suggestion that beta-endorphin, released from the pituitary, may mediate these analgesic reactions. "Long-term analgesia" (an opioid-mediated form of stress-induced analgesia), which is blocked by dexamethasone and hypophysectomy, was also blocked by adrenalectomy and reinstated with corticosterone therapy. Corticosterone is proposed to play a permissive role in long-term analgesia and to be a critical hormone mediating this phenomenon.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Pituitary-Adrenocortical Responses to Persistent Noxious Stimuli in the Awake Rat: Endogenous Corticosterone Does Not Reduce Nociception in the Formalin Test.
B. K. Taylor, S. F. Akana, M. A. Peterson, M. F. Dallman, and A. I. Basbaum (1998)
Endocrinology 139, 2407-2413
   Abstract »    Full Text »    PDF »
Intrinsic mechanisms of pain inhibition: activation by stress.
G. Terman, Y Shavit, J. Lewis, J. Cannon, and J. Liebeskind (1984)
Science 226, 1270-1277
   Abstract »    PDF »
Immunoreactive dynorphin-(1-8) and corticotropin- releasing factor in subpopulation of hypothalamic neurons.
K. Roth, E Weber, J. Barchas, D Chang, and J. Chang (1983)
Science 219, 189-191
   Abstract »    PDF »
Adrenal medullary enkephalin-like peptides may mediate opioid stress analgesia.
J. Lewis, M. Tordoff, J. Sherman, and J. Liebeskind (1982)
Science 217, 557-559
   Abstract »    PDF »


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