Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 19 March 1982:
Vol. 215. no. 4539, pp. 1518 - 1519
DOI: 10.1126/science.7063860
Prev | Table of Contents | Next

Articles

Science, Vol 215, Issue 4539, 1518-1519
Copyright © 1982 by American Association for the Advancement of Science

articles

Obesity and adipocyte abnormalities in offspring of rats undernourished during pregnancy

AP Jones and MI Friedman

Pregnant rats underfed in the first 2 weeks of gestation had offspring with normal body weight at birth and weaning. However, starting at about 5 weeks of age the male offspring became hyperphagic and gained more weight than the controls. The female offspring did not overeat and did not become obese. Both male and female progeny showed increased fat cell size as adults. In males the epididymal and retroperitoneal fat pads were significantly enlarged nd adipocytes in these pads were hypertrophied. In females and fat pads were not enlarged, but adipocytes in the parametrial pads were hypertrophied.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Programmed Alterations in Hypothalamic Neuronal Orexigenic Responses to Ghrelin Following Gestational Nutrient Restriction.
Yousheng Jia, T. Nguyen, M. Desai, and M. G. Ross (2008)
Reproductive Sciences 15, 702-709
   Abstract »    PDF »
The Global Epidemic of Obesity: An Overview.
B. Caballero (2007)
Epidemiol. Rev.
   Full Text »    PDF »
Prevention of diet-induced obesity and impaired glucose tolerance in rats following administration of leptin to their mothers.
C. J. Stocker, E. Wargent, J. O'Dowd, C. Cornick, J. R. Speakman, J. R. S. Arch, and M. A. Cawthorne (2007)
Am J Physiol Regulatory Integrative Comp Physiol 292, R1810-R1818
   Abstract »    Full Text »    PDF »
Regulation of leptin synthesis and secretion before birth: implications for the early programming of adult obesity..
I C McMillen, L J Edwards, J Duffield, and B S Muhlhausler (2006)
Reproduction 131, 415-427
   Abstract »    Full Text »    PDF »
F-DIO obesity-prone rat is insulin resistant before obesity onset.
B. E. Levin, C. Magnan, S. Migrenne, S. C. Chua Jr., and A. A. Dunn-Meynell (2005)
Am J Physiol Regulatory Integrative Comp Physiol 289, R704-R711
   Abstract »    Full Text »    PDF »
Early origins of obesity: programming the appetite regulatory system.
I. C. McMillen, C. L. Adam, and B. S. Muhlhausler (2005)
J. Physiol. 565, 9-17
   Abstract »    Full Text »    PDF »
Effect of a high or low ambient perinatal temperature on adult obesity in Osborne-Mendel and S5B/Pl rats.
C. L. White, H. D. Braymer, D. A. York, and G. A. Bray (2005)
Am J Physiol Regulatory Integrative Comp Physiol 288, R1376-R1384
   Abstract »    Full Text »    PDF »
Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming.
I. C. Mcmillen and J. S. Robinson (2005)
Physiol Rev 85, 571-633
   Abstract »    Full Text »    PDF »
Impact of periconceptional nutrition on maternal and fetal leptin and fetal adiposity in singleton and twin pregnancies.
L. J. Edwards, J. R. McFarlane, K. G. Kauter, and I. C. McMillen (2005)
Am J Physiol Regulatory Integrative Comp Physiol 288, R39-R45
   Abstract »    Full Text »    PDF »
Chronic maternal feed restriction impairs growth but increases adiposity of the fetal guinea pig.
K. L. Kind, C. T. Roberts, A. I. Sohlstrom, A. Katsman, P. M. Clifton, J. S. Robinson, and J. A. Owens (2005)
Am J Physiol Regulatory Integrative Comp Physiol 288, R119-R126
   Abstract »    Full Text »    PDF »
The effects of birth weight and postnatal growth patterns on fat depth and plasma leptin concentrations in juvenile and adult pigs.
K. R. Poore and A. L. Fowden (2004)
J. Physiol. 558, 295-304
   Abstract »    Full Text »    PDF »
Minireview: Leptin and Development of Hypothalamic Feeding Circuits.
S. G. Bouret and R. B. Simerly (2004)
Endocrinology 145, 2621-2626
   Abstract »    Full Text »    PDF »
Endocrine mechanisms of intrauterine programming.
A L Fowden and A J Forhead (2004)
Reproduction 127, 515-526
   Abstract »    Full Text »    PDF »
Maternal obesity alters adiposity and monoamine function in genetically predisposed offspring.
B. E. Levin and A. A. Dunn-Meynell (2002)
Am J Physiol Regulatory Integrative Comp Physiol 283, R1087-R1093
   Abstract »    Full Text »    PDF »
Animal models and programming of the metabolic syndrome: Type 2 diabetes.
C. E Bertram and M. A Hanson (2001)
Br. Med. Bull. 60, 103-121
   Abstract »    Full Text »    PDF »
Fetal experience and good adult design.
P. Bateson (2001)
Int. J. Epidemiol. 30, 928-934
   Full Text »    PDF »
Maternal Endotoxemia Results in Obesity and Insulin Resistance in Adult Male Offspring.
C. Nilsson, B.-M. Larsson, E. Jennische, E. Eriksson, P. Bjorntorp, D. A. York, and A. Holmang (2001)
Endocrinology 142, 2622-2630
   Abstract »    Full Text »    PDF »
Fatness and body mass index from birth to young adulthood in a rural Guatemalan population.
D. G Schroeder and R. Martorell (1999)
Am. J. Clinical Nutrition 70 , 137S-144S
   Abstract »    Full Text »    PDF »
Potential mechanisms of metabolic imprinting that lead to chronic disease.
R. A Waterland and C. Garza (1999)
Am. J. Clinical Nutrition 69, 179-197
   Abstract »    Full Text »    PDF »
Intrauterine nutrition: its importance during critical periods for cardiovascular and endocrine development.
J J Hoet and M A Hanson (1999)
J. Physiol. 514, 617-627
   Abstract »    Full Text »    PDF »
Gestational obesity accentuates obesity in obesity-prone progeny.
B. E. Levin and E. Govek (1998)
Am J Physiol Regulatory Integrative Comp Physiol 275, R1374-R1379
   Abstract »    Full Text »    PDF »
Prenatal food restriction and subsequent weight gain in male rats.
M. Enns, M. Wilson, J. Grinker, I. Faust, A. Jones, and M. Friedman (1983)
Science 219, 1093-1094
   PDF »
Prenatal Food Restriction and Subsequent Weight Gain in Male Rats.
A. P. JONES and M. I. FRIEDMAN (1983)
Science 219, 1094
   PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)