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Science 12 March 1982:
Vol. 215. no. 4538, pp. 1420 - 1421
DOI: 10.1126/science.6278594
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Articles

Science, Vol 215, Issue 4538, 1420-1421
Copyright © 1982 by American Association for the Advancement of Science

articles

Peptide and steroid regulation of muscle degeneration in an insect

LM Schwartz and JW Truman

Two types of cell death occur in the intersegmental muscles of the giant silkmoth Antheraea polyphemus. The first results from a slow atrophy of the fibers, and the second is a rapid, programmed dissolution of the muscle. Both types appear to be mediated by endocrine factors. The slow atrophy is brought about by the decline in the steroid molting hormone 20-hydroxyecdysone and can be prevented with exogenous steroid. The rapid degeneration is triggered by the peptide eclosion hormone, but the sensitivity of the muscle to the peptide depends on the history of exposure of the muscle to 20-hydroxyecdysone.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Steroid regulated programmed cell death during Drosophila metamorphosis.
C Jiang, E. Baehrecke, and C. Thummel (1997)
Development 124, 4673-4683
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Steroid-dependent survival of identifiable neurons in cultured ganglia of the moth Manduca sexta.
K. Bennett and J. Truman (1985)
Science 229, 58-60
   Abstract »    PDF »


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