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Science 12 March 1982:
Vol. 215. no. 4538, pp. 1415 - 1418
DOI: 10.1126/science.7063854
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Articles

Science, Vol 215, Issue 4538, 1415-1418
Copyright © 1982 by American Association for the Advancement of Science

articles

Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence

R Weindruch and RL Walford

Lifelong dietary restriction beginning at 3 to 6 weeks of age in rodents is known to decelerate the rate of aging, increase mean and maximum life-spans, and inhibit the occurrence of many spontaneous cancers. Little is known about the effects of dietary restriction started in middle age. In the experiments now reported the food intake of 12- to 13-month-old mice of two long-lived strains was restricted by using nutrient-enriched diets in accordance with the concept of "undernutrition without malnutrition." The mice on the restricted diet averaged 10 to 20 percent increases in mean and maximum survival times compared to the control mice. Spontaneous lymphoma was inhibited by the food restriction.


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