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Science 12 March 1982:
Vol. 215. no. 4538, pp. 1394 - 1396
DOI: 10.1126/science.6278591
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Articles
Science, Vol 215, Issue 4538, 1394-1396
Copyright © 1982 by American Association for the Advancement of Science
alpha 2-adrenoceptor-mediated hyperpolarization of locus coeruleus neurons: intracellular studies in vivo
GK Aghajanian
and
CP VanderMaelen
Intracellular recordings in vivo from noradrenergic neurons in the rat locus coeruleus showed that membrane potential was hyperpolarized by the administration of clonidine (an alpha 2-adrenoceptor agonist) or after a burst of spikes evoked by intracellular pulses; both types of hyperpolarization were associated with a decrease in membrane input resistance, and both could be blocked by the alpha 2-adrenoceptor antagonist piperoxane. These results suggest that a hyperpolarization of membrane potential mediated by an alpha 2-adrenoceptor underlies both clonidine- and activation-induced inhibition of locus coeruleus cell firing.
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