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Science 5 March 1982:
Vol. 215. no. 4537, pp. 1267 - 1268
DOI: 10.1126/science.7058347
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Articles

Science, Vol 215, Issue 4537, 1267-1268
Copyright © 1982 by American Association for the Advancement of Science

articles

In vivo mapping of local cerebral blood flow by xenon-enhanced computed tomography

D Gur, WF Good, SK Wolfson Jr, H Yonas, and L Shabason

A noninvasive technique has been developed to measure and display local cerebral blood flow (LCBF) in vivo. In this procedure, nonradioactive xenon gas is inhaled and the temporal changes in radiographic enhancement produced by the inhalation are measured by sequential computerized tomography. The time-dependent xenon concentrations in various anatomical units in the brain are used to derive both the local partition coefficient and the LCBF. Functional mapping of blood flow with excellent anatomical specificity has been obtained in the baboon brain. The response of LCBF to stimuli such as changes in carbon dioxide concentrations as well as the variability in LCBF in normal and diseased tissue can be easily demonstrated. This method is applicable to the study of human physiology and pathologic blood flow alterations.


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