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Science 5 March 1982:
Vol. 215. no. 4537, pp. 1245 - 1247
DOI: 10.1126/science.6460317
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Articles

Science, Vol 215, Issue 4537, 1245-1247
Copyright © 1982 by American Association for the Advancement of Science

articles

Autoantibodies to nucleosomal proteins: antibodies to HMG-17 in autoimmune diseases

M Bustin, J Reisch, L Einck, and JH Klippel

The relative amounts of autoantibodies against defined nucleosomal proteins present in serums from patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and mixed connective tissue disease (MCTD) have been examined by an enzyme-linked immunoassay. Autoantibodies to nucleosomal proteins were detected in 45 percent of the patients with SLE, 18 percent of the MCTD patients, and none of the RA patients. The results suggest that, in SLE, antibodies are formed against a subset of nucleosomes which contain protein HMG-17.


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