Science 5 March 1982: Vol. 215. no. 4537, pp. 1237 - 1239 DOI: 10.1126/science.7058341

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Articles

Retinoic Acid Attenuates {beta}-Amyloid Deposition and Rescues Memory Deficits in an Alzheimer's Disease Transgenic Mouse Model.

Y. Ding, A. Qiao, Z. Wang, J. S. Goodwin, E.-S. Lee, M. L. Block, M. Allsbrook, M. P. McDonald, and G.-H. Fan (2008)
J. Neurosci. 28, 11622-11634
 |  Abstract »  |  Full Text »  |  PDF »

Dementia of the Alzheimer Type.

J. J. Jalbert, L. A. Daiello, and K. L. Lapane (2008)
Epidemiol. Rev. 30, 15-34
 |  Abstract »  |  Full Text »  |  PDF »

Long-Term Changes in the Muscarinic M1 Receptor Induced by Instantaneous Formation of Wash-Resistant Xanomeline-Receptor Complex.

K. C. De Lorme, M. K.O. Grant, M. J. Noetzel, S. B. Polson, and E. E. El-Fakahany (2007)
J. Pharmacol. Exp. Ther. 323, 868-876
 |  Abstract »  |  Full Text »  |  PDF »

Peripheral ethanolamine plasmalogen deficiency: a logical causative factor in Alzheimer's disease and dementia.

D. B. Goodenowe, L. L. Cook, J. Liu, Y. Lu, D. A. Jayasinghe, P. W. K. Ahiahonu, D. Heath, Y. Yamazaki, J. Flax, K. F. Krenitsky, et al. (2007)
J. Lipid Res. 48, 2485-2498
 |  Abstract »  |  Full Text »  |  PDF »

Muscarinic Receptor Dependent Long-Term Depression in Rat Visual Cortex Is PKC Independent but Requires ERK1/2 Activation and Protein Synthesis.

P. A. McCoy and L. L. McMahon (2007)
J Neurophysiol 98, 1862-1870
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid {beta} Protein Modulates Glutamate-Mediated Neurotransmission in the Rat Basal Forebrain: Involvement of Presynaptic Neuronal Nicotinic Acetylcholine and Metabotropic Glutamate Receptors.

J. H. Chin, L. Ma, D. MacTavish, and J. H. Jhamandas (2007)
J. Neurosci. 27, 9262-9269
 |  Abstract »  |  Full Text »  |  PDF »

Role of Neuroimaging in Alzheimer's Disease, with Emphasis on Brain Perfusion SPECT.

H. Matsuda (2007)
J. Nucl. Med. 48, 1289-1300
 |  Abstract »  |  Full Text »  |  PDF »

Should One Use Medications in Combination With Cognitive Training? If So, Which Ones?.

J. Yesavage, J. Hoblyn, L. Friedman, M. Mumenthaler, B. Schneider, and R. O'Hara (2007)
J. Gerontol. B. Psychol. Sci. Soc. Sci. 62, 11-18
 |  Abstract »  |  Full Text »  |  PDF »

References.

(2007)
PsychiatryOnline CME 2007, 2
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Preclinical Investigation of the Topical Administration of Phenserine: Transdermal Flux, Cholinesterase Inhibition, and Cognitive Efficacy.

T. Utsuki, N. Uchimura, M. Irikura, H. Moriuchi, H. W. Holloway, Q.-S. Yu, E. L. Spangler, J. Mamczarz, D. K. Ingram, T. Irie, et al. (2007)
J. Pharmacol. Exp. Ther. 321, 353-361
 |  Abstract »  |  Full Text »  |  PDF »

Neuronal Pentraxin 1 Contributes to the Neuronal Damage Evoked by Amyloid-{beta} and Is Overexpressed in Dystrophic Neurites in Alzheimer's Brain.

M. A. Abad, M. Enguita, N. DeGregorio-Rocasolano, I. Ferrer, and R. Trullas (2006)
J. Neurosci. 26, 12735-12747
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer's centennial legacy: origins, landmarks and the current status of knowledge concerning cognitive aspects..

J. R. Hodges (2006)
Brain 129, 2811-2822
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer's Disease and the Aging Brain.

R. D. Terry (2006)
J Geriatr Psychiatry Neurol 19, 125-128
 |  Abstract »  |  PDF »

Interaction Studies of Multiple Binding Sites on M4 Muscarinic Acetylcholine Receptors.

A. A. Lanzafame, P. M. Sexton, and A. Christopoulos (2006)
Mol. Pharmacol. 70, 736-746
 |  Abstract »  |  Full Text »  |  PDF »

The Caenorhabditis elegans choline transporter CHO-1 sustains acetylcholine synthesis and motor function in an activity-dependent manner..

D. S. Matthies, P. A. Fleming, D. M. Wilkes, and R. D. Blakely (2006)
J. Neurosci. 26, 6200-6212
 |  Abstract »  |  Full Text »  |  PDF »

Estrogen Induces Estrogen Receptor {alpha}-Dependent cAMP Response Element-Binding Protein Phosphorylation via Mitogen Activated Protein Kinase Pathway in Basal Forebrain Cholinergic Neurons In Vivo.

E. M. Szego, K. Barabas, J. Balog, N. Szilagyi, K. S. Korach, G. Juhasz, and I. M. Abraham (2006)
J. Neurosci. 26, 4104-4110
 |  Abstract »  |  Full Text »  |  PDF »

Simultaneous Release of Glutamate and Acetylcholine from Single Magnocellular "Cholinergic" Basal Forebrain Neurons.

T. G.J. Allen, F. C. Abogadie, and D. A. Brown (2006)
J. Neurosci. 26, 1588-1595
 |  Abstract »  |  Full Text »  |  PDF »

Ectopic Cell Cycle Events Link Human Alzheimer's Disease and Amyloid Precursor Protein Transgenic Mouse Models.

Y. Yang, N. H. Varvel, B. T. Lamb, and K. Herrup (2006)
J. Neurosci. 26, 775-784
 |  Abstract »  |  Full Text »  |  PDF »

Neuroanatomy/pathology and the interplay of neurotransmitters in moderate to severe Alzheimer disease.

P. T. Francis (2005)
Neurology 65, S5-S9
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Nerve Growth Factor Rapidly Increases Muscarinic Tone in Mouse Medial Septum/Diagonal Band of Broca.

C.-w. K. Wu and H. H. Yeh (2005)
J. Neurosci. 25, 4232-4242
 |  Abstract »  |  Full Text »  |  PDF »

Cholinesterase Inhibitors in the Treatment of Dementia.

J. M. Ellis (2005)
J Am Osteopath Assoc 105, 145-158
 |  Abstract »  |  Full Text »  |  PDF »

Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer's Disease.

G. B. Stokin, C. Lillo, T. L. Falzone, R. G. Brusch, E. Rockenstein, S. L. Mount, R. Raman, P. Davies, E. Masliah, D. S. Williams, et al. (2005)
Science 307, 1282-1288
 |  Abstract »  |  Full Text »  |  PDF »

Spike Patterning by Ca2+-Dependent Regulation of a Muscarinic Cation Current in Entorhinal Cortex Layer II Neurons.

J. Magistretti, L. Ma, M. H. Shalinsky, W. Lin, R. Klink, and A. Alonso (2004)
J Neurophysiol 92, 1644-1657
 |  Abstract »  |  Full Text »  |  PDF »

Group I Metabotropic Glutamate Receptor Activation Produces a Direct Excitation of Identified Septohippocampal Cholinergic Neurons.

M. Wu, T. Hajszan, C. Xu, C. Leranth, and M. Alreja (2004)
J Neurophysiol 92, 1216-1225
 |  Abstract »  |  Full Text »  |  PDF »

Par-4 Inhibits Choline Uptake by Interacting with CHT1 and Reducing Its Incorporation on the Plasma Membrane.

J. Xie and Q. Guo (2004)
J. Biol. Chem. 279, 28266-28275
 |  Abstract »  |  Full Text »  |  PDF »

Lethal impairment of cholinergic neurotransmission in hemicholinium-3-sensitive choline transporter knockout mice.

S. M. Ferguson, M. Bazalakova, V. Savchenko, J. C. Tapia, J. Wright, and R. D. Blakely (2004)
PNAS 101, 8762-8767
 |  Abstract »  |  Full Text »  |  PDF »

Acetylcholinesterase-A{beta} Complexes Are More Toxic than A{beta} Fibrils in Rat Hippocampus: Effect on Rat {beta}-Amyloid Aggregation, Laminin Expression, Reactive Astrocytosis, and Neuronal Cell Loss.

A. E. Reyes, M. A. Chacon, M. C. Dinamarca, W. Cerpa, C. Morgan, and N. C. Inestrosa (2004)
Am. J. Pathol. 164, 2163-2174
 |  Abstract »  |  Full Text »  |  PDF »

The Choline Transporter Resurfaces: New Roles for Synaptic Vesicles?.

S. M. Ferguson and R. D. Blakely (2004)
Mol. Interv. 4, 22-37
 |  Abstract »  |  Full Text »  |  PDF »

Acetylcholine, Histamine, and Cognition: Two Sides of the Same Coin.

P. Blandina, M. Efoudebe, G. Cenni, P. Mannaioni, and M. B. Passani (2004)
Learn. Mem. 11, 1-8
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Cholinergic Modulation of Visual Attention and Working Memory: Dissociable Effects of Basal Forebrain 192-IgG-saporin Lesions and Intraprefrontal Infusions of Scopolamine.

Y. Chudasama, J. W. Dalley, F. Nathwani, P. Bouger, and T. W. Robbins (2004)
Learn. Mem. 11, 78-86
 |  Abstract »  |  Full Text »  |  PDF »

Acetylcholinesterase Inhibitors Activate Septohippocampal GABAergic Neurons via Muscarinic but Not Nicotinic Receptors.

M. Wu, S. S. Newton, J. B. Atkins, C. Xu, R. S. Duman, and M. Alreja (2003)
J. Pharmacol. Exp. Ther. 307, 535-543
 |  Abstract »  |  Full Text »  |  PDF »

Looking Backward to Move Forward: Early Detection of Neurodegenerative Disorders.

S. T. DeKosky and K. Marek (2003)
Science 302, 830-834
 |  Abstract »  |  Full Text »  |  PDF »

Nicotinic Acetylcholine Receptor-Mediated Neuroprotection by Donepezil Against Glutamate Neurotoxicity in Rat Cortical Neurons.

Y. Takada, A. Yonezawa, T. Kume, H. Katsuki, S. Kaneko, H. Sugimoto, and A. Akaike (2003)
J. Pharmacol. Exp. Ther. 306, 772-777
 |  Abstract »  |  Full Text »  |  PDF »

The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain.

Y. Zhao, O. Marin, E. Hermesz, A. Powell, N. Flames, M. Palkovits, J. L. R. Rubenstein, and H. Westphal (2003)
PNAS 100, 9005-9010
 |  Abstract »  |  Full Text »  |  PDF »

Impaired Modulation of GABAergic Transmission by Muscarinic Receptors in a Mouse Transgenic Model of Alzheimer's Disease.

P. Zhong, Z. Gu, X. Wang, H. Jiang, J. Feng, and Z. Yan (2003)
J. Biol. Chem. 278, 26888-26896
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Muscarinic Receptors Inhibits beta -Amyloid Peptide-induced Signaling in Cortical Slices.

Z. Gu, P. Zhong, and Z. Yan (2003)
J. Biol. Chem. 278, 17546-17556
 |  Abstract »  |  Full Text »  |  PDF »

Neuronal Cell Death Is Preceded by Cell Cycle Events at All Stages of Alzheimer's Disease.

Y. Yang, E. J. Mufson, and K. Herrup (2003)
J. Neurosci. 23, 2557-2563
 |  Abstract »  |  Full Text »  |  PDF »

MRI as a biomarker of disease progression in a therapeutic trial of milameline for AD.

C. R. Jack Jr., M. Slomkowski, S. Gracon, T. M. Hoover, J. P. Felmlee, K. Stewart, Y. Xu, M. Shiung, P. C. O'Brien, R. Cha, et al. (2003)
Neurology 60, 253-260
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer's Disease Is a Synaptic Failure.

D. J. Selkoe (2002)
Science 298, 789-791
 |  Abstract »  |  Full Text »  |  PDF »

Early and Widespread Cholinergic Losses Differentiate Dementia With Lewy Bodies From Alzheimer Disease.

P. Tiraboschi, L. A. Hansen, M. Alford, A. Merdes, E. Masliah, L. J. Thal, and J. Corey-Bloom (2002)
Arch Gen Psychiatry 59, 946-951
 |  Abstract »  |  Full Text »  |  PDF »

The Role of Hormone Replacement Therapy in the Prevention of Alzheimer Disease.

H. M. Fillit (2002)
Arch Intern Med 162, 1934-1942
 |  Abstract »  |  Full Text »  |  PDF »

Noninvasive in vivo assessment of cholinergic cortical circuits in AD using transcranial magnetic stimulation.

V. Di Lazzaro, A. Oliviero, P. A. Tonali, C. Marra, A. Daniele, P. Profice, E. Saturno, F. Pilato, C. Masullo, and J. C. Rothwell (2002)
Neurology 59, 392-397
 |  Abstract »  |  Full Text »  |  PDF »

Unilateral Lesions of the Cholinergic Basal Forebrain and Fornix in One Hemisphere and Inferior Temporal Cortex in the Opposite Hemisphere Produce Severe Learning Impairments in Rhesus Monkeys.

A. Easton, R.M. Ridley, H.F. Baker, and D. Gaffan (2002)
Cereb Cortex 12, 729-736
 |  Abstract »  |  Full Text »  |  PDF »

Cholinergic Changes in the APP23 Transgenic Mouse Model of Cerebral Amyloidosis.

S. Boncristiano, M. E. Calhoun, P. H. Kelly, M. Pfeifer, L. Bondolfi, M. Stalder, A. L. Phinney, D. Abramowski, C. Sturchler-Pierrat, A. Enz, et al. (2002)
J. Neurosci. 22, 3234-3243
 |  Abstract »  |  Full Text »  |  PDF »

Aging Causes a Preferential Loss of Cholinergic Innervation of Characterized Neocortical Pyramidal Neurons.

M. A. Casu, T. Pan Wong, Y. De Koninck, A. Ribeiro-da-Silva, and A. C. Cuello (2002)
Cereb Cortex 12, 329-337
 |  Abstract »  |  Full Text »  |  PDF »

Use of cholinesterase inhibitors in dementia.

M. Holden and C. Kelly (2002)
Advan. Psychiatr. Treat. 8, 89-96
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Stable {beta}-Secretase Activity and Presynaptic Cholinergic Markers During Progressive Central Nervous System Amyloidogenesis in Tg2576 Mice.

J.-T. Gau, M. L. Steinhilb, T.-C. Kao, C. J. D'Amato, J. R. Gaut, K. A. Frey, and R. S. Turner (2002)
Am. J. Pathol. 160, 731-738
 |  Abstract »  |  Full Text »  |  PDF »

MR Analysis of the Substantia Innominata in Normal Aging, Alzheimer Disease, and Other Types of Dementia.

H. Hanyu, T. Asano, H. Sakurai, Y. Tanaka, M. Takasaki, and K. Abe (2002)
AJNR Am. J. Neuroradiol. 23, 27-32
 |  Abstract »  |  Full Text »  |  PDF »

Past Glory and Future Promise: Maximizing and Improving Understanding of Atrophy Patterns in the Diagnosis of Degenerative Dementias.

B. L. Miller (2002)
AJNR Am. J. Neuroradiol. 23, 33-34
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Apolipoprotein E {epsilon}4 and the pattern of regional brain atrophy in Alzheimer's disease.

M. Hashimoto, M. Yasuda, S. Tanimukai, M. Matsui, N. Hirono, H. Kazui, and E. Mori (2001)
Neurology 57, 1461-1466
 |  Abstract »  |  Full Text »  |  PDF »

Hyper-expression of human apolipoprotein E4 in astroglia and neurons does not enhance amyloid deposition in transgenic mice.

C. Lesuisse, G. Xu, J. Anderson, M. Wong, J. Jankowsky, G. Holtz, V. Gonzalez, P. C. Y. Wong, D. L. Price, F. Tang, et al. (2001)
Hum. Mol. Genet. 10, 2525-2537
 |  Abstract »  |  Full Text »  |  PDF »

Psychosis of Alzheimer's disease is associated with elevated muscarinic M2 binding in the cortex.

M. K. P. Lai, O. -F. Lai, J. Keene, M. M. Esiri, P. T. Francis, T. Hope, and C. P.L.-H. Chen (2001)
Neurology 57, 805-811
 |  Abstract »  |  Full Text »  |  PDF »

Synthesis and Pharmacological Evaluation of Dimeric Muscarinic Acetylcholine Receptor Agonists.

A. Christopoulos, M. K. O. Grant, N. Ayoubzadeh, O. N. Kim, P. Sauerberg, L. Jeppesen, and E. E. El-Fakahany (2001)
J. Pharmacol. Exp. Ther. 298, 1260-1268
 |  Abstract »  |  Full Text »  |  PDF »

DNA Replication Precedes Neuronal Cell Death in Alzheimer's Disease.

Y. Yang, D. S. Geldmacher, and K. Herrup (2001)
J. Neurosci. 21, 2661-2668
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid Precursor Protein in Platelets of Patients With Alzheimer Disease: Effect of Acetylcholinesterase Inhibitor Treatment.

B. Borroni, F. Colciaghi, L. Pastorino, C. Pettenati, E. Cottini, L. Rozzini, R. Monastero, G. L. Lenzi, F. Cattabeni, M. Di Luca, et al. (2001)
Arch Neurol 58, 442-446
 |  Abstract »  |  Full Text »  |  PDF »

Long-Lasting Cholinergic Modulation Underlies Rule Learning in Rats.

D. Saar, Y. Grossman, and E. Barkai (2001)
J. Neurosci. 21, 1385-1392
 |  Abstract »  |  Full Text »  |  PDF »

The decline in synapses and cholinergic activity is asynchronous in Alzheimer's disease.

P. Tiraboschi, L. A. Hansen, M. Alford, E. Masliah, L. J. Thal, and J. Corey-Bloom (2000)
Neurology 55, 1278-1283
 |  Abstract »  |  Full Text »  |  PDF »

Muscarinic Tone Sustains Impulse Flow in the Septohippocampal GABA But Not Cholinergic Pathway: Implications for Learning and Memory.

M. Alreja, M. Wu, W. Liu, J. B. Atkins, C. Leranth, and M. Shanabrough (2000)
J. Neurosci. 20, 8103-8110
 |  Abstract »  |  Full Text »  |  PDF »

Galantamine in AD: A 6-month randomized, placebo-controlled trial with a 6-month extension.

M. A. Raskind, E. R. Peskind, T. Wessel, and W. Yuan (2000)
Neurology 54, 2261-2268
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice.

S. Capsoni, G. Ugolini, A. Comparini, F. Ruberti, N. Berardi, and A. Cattaneo (2000)
PNAS 97, 6826-6831
 |  Abstract »  |  Full Text »  |  PDF »

Cholinergic Excitation of Septohippocampal GABA But Not Cholinergic Neurons: Implications for Learning and Memory.

M. Wu, M. Shanabrough, C. Leranth, and M. Alreja (2000)
J. Neurosci. 20, 3900-3908
 |  Abstract »  |  Full Text »  |  PDF »

Role of High-Affinity Receptors and Membrane Transporters in Nonsynaptic Communication and Drug Action in the Central Nervous System.

E. S. Vizi (2000)
Pharmacol. Rev. 52, 63-90
 |  Abstract »  |  Full Text »  |  PDF »

Nicotine Enhances the Biosynthesis and Secretion of Transthyretin from the Choroid Plexus in Rats: Implications for beta -Amyloid Formation.

M. D. Li, J. K. Kane, S. G. Matta, W. S. Blaner, and B. M. Sharp (2000)
J. Neurosci. 20, 1318-1323
 |  Abstract »  |  Full Text »  |  PDF »

Pharmacological Characterization of Endogenous Acetylcholine Release from Primary Septal Cultures.

D. S. Auld, J. C. Day, F. Mennicken, and R. Quirion (2000)
J. Pharmacol. Exp. Ther. 292, 692-697
 |  Abstract »  |  Full Text »

Extended-Release Physostigmine in Alzheimer Disease: A Multicenter, Double-blind, 12-Week Study With Dose Enrichment.

C. H. van Dyck, P. Newhouse, W. E. Falk, J. A. Mattes, and for the Physostigmine Study Group (2000)
Arch Gen Psychiatry 57, 157-164
 |  Abstract »  |  Full Text »  |  PDF »

Lu 25-109, a muscarinic agonist, fails to improve cognition in Alzheimer's disease.

L. J. Thal, M. Forrest, H. Loft, and H. Mengel (2000)
Neurology 54, 421
 |  Abstract »  |  Full Text »  |  PDF »

Cholinergic Markers in Alzheimer Disease.

R. T. Bartus, D. F. Emerich, K. L. Davis, D. Marin, D. P. Purohit, D. Perl, M. Lantz, G. Austin, and V. Haroutunian (1999)
JAMA 282, 2208-2209
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Interaction of Alzheimer's Presenilin-1 and Presenilin-2 with Bcl-XL. A POTENTIAL ROLE IN MODULATING THE THRESHOLD OF CELL DEATH.

B. J. Passer, L. Pellegrini, P. Vito, J. K. Ganjei, and L. D'Adamio (1999)
J. Biol. Chem. 274, 24007-24013
 |  Abstract »  |  Full Text »  |  PDF »

Failure to confirm a synergistic effect between the K-variant of the butyrylcholinesterase gene and the epsilon 4 allele of the apolipoprotein gene in Japanese patients with Alzheimer's disease.

Y. Yamamoto, M. Yasuda, E. Mori, and K. Maeda (1999)
J. Neurol. Neurosurg. Psychiatry 67, 94-96
 |  Abstract »  |  Full Text »

Pharmacological Analysis of the Novel Mode of Interaction between Xanomeline and the M1 Muscarinic Acetylcholine Receptor.

A. Christopoulos, A. M. Parsons, and E. E. El-Fakahany (1999)
J. Pharmacol. Exp. Ther. 289, 1220-1228
 |  Abstract »  |  Full Text »

Reversible inactivation of the nucleus basalis magnocellularis induces disruption of cortical acetylcholine release and acquisition, but not retrieval, of aversive memories.

M. I. Miranda and F. Bermudez-Rattoni (1999)
PNAS 96, 6478-6482
 |  Abstract »  |  Full Text »  |  PDF »

Reorganization of Cholinergic Terminals in the Cerebral Cortex and Hippocampus in Transgenic Mice Carrying Mutated Presenilin-1 and Amyloid Precursor Protein Transgenes.

T. P. Wong, T. Debeir, K. Duff, and A. C. Cuello (1999)
J. Neurosci. 19, 2706-2716
 |  Abstract »  |  Full Text »  |  PDF »

The cholinergic hypothesis of Alzheimer's disease: a review of progress.

P. T Francis, A. M Palmer, M. Snape, and G. K Wilcock (1999)
J. Neurol. Neurosurg. Psychiatry 66, 137-147
 |  Abstract »  |  Full Text »

The Neurobiology and Pharmacotherapy of Alzheimer's Disease.

O. Felician and T. A. Sandson (1999)
J Neuropsychiatry Clin Neurosci 11, 19-31
 |  Abstract »  |  Full Text »

Experimental Therapeutics of Neurodegenerative Disorders: Unmet Needs.

I. Shoulson (1998)
Science 282, 1072-1074
 |  Abstract »  |  Full Text »

Morphological and Membrane Properties of Rat Magnocellular Basal Forebrain Neurons Maintained in Culture.

J. A. Sim and T.G.J. Allen (1998)
J Neurophysiol 80, 1653-1669
 |  Abstract »  |  Full Text »  |  PDF »

Aggravated decrease in the activity of nucleus basalis neurons in Alzheimer's disease is apolipoprotein E-type dependent.

A. Salehi, E. J. G. Dubelaar, M. Mulder, and D. F. Swaab (1998)
PNAS 95, 11445-11449
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the genetically defined m1 muscarinic receptor potentiates N-methyl-D-aspartate (NMDA) receptor currents in hippocampal pyramidal cells.

M. J. Marino, S. T. Rouse, A. I. Levey, L. T. Potter, and P. J. Conn (1998)
PNAS 95, 11465-11470
 |  Abstract »  |  Full Text »  |  PDF »

Dementia with parkinsonism: Alzheimer's disease is more common than dementia with Lewy bodies.

C. F. Lippa, T. W. Smith, and J. Swearer (1998)
American Journal of Alzheimer's Disease and Other Dementias 13, 229-235
 |  Abstract »  |  PDF »

Coadministration of Galanin Antagonist M40 with a Muscarinic M1 Agonist Improves Delayed Nonmatching to Position Choice Accuracy in Rats with Cholinergic Lesions.

M. P. McDonald, L. B. Willard, G. L. Wenk, and J. N. Crawley (1998)
J. Neurosci. 18, 5078-5085
 |  Abstract »  |  Full Text »  |  PDF »

Increasing Required Neural Response to Expose Abnormal Brain Function in Mild Versus Moderate or Severe Alzheimer's Disease: PET Study Using Parametric Visual Stimulation.

M. J. Mentis, G. E. Alexander, J. Krasuski, P. Pietrini, M. L. Furey, M. B. Schapiro, and S. I. Rapoport (1998)
Am J Psychiatry 155, 785-794
 |  Abstract »  |  Full Text »

Distinctive Morphological Features of a Subset of Cortical Neurons Grown in the Presence of Basal Forebrain Neurons In Vitro.

D. H. Ha, R. T. Robertson, and J. H. Weiss (1998)
J. Neurosci. 18, 4201-4215
 |  Abstract »  |  Full Text »  |  PDF »

Increased Synaptic Sprouting in Response to Estrogen via an Apolipoprotein E-Dependent Mechanism: Implications for Alzheimer's Disease.

D. J. Stone, I. Rozovsky, T. E. Morgan, C. P. Anderson, and C. E. Finch (1998)
J. Neurosci. 18, 3180-3185
 |  Abstract »  |  Full Text »  |  PDF »

Ectopic Cell Cycle Proteins Predict the Sites of Neuronal Cell Death in Alzheimer's Disease Brain.

J. Busser, D. S. Geldmacher, and K. Herrup (1998)
J. Neurosci. 18, 2801-2807
 |  Abstract »  |  Full Text »  |  PDF »

Ca2+-permeable non-NMDA glutamate receptors in rat magnocellular basal forebrain neurones.

D J. Waters and T. G J Allen (1998)
J. Physiol. 508, 453-469
 |  Abstract »  |  Full Text »  |  PDF »

Effects of U-50,488H on Scopolamine-, Mecamylamine- and Dizocilpine-Induced Learning and Memory Impairment in Rats.

M. Hiramatsu, H. Murasawa, T. Nabeshima, and T. Kameyama (1998)
J. Pharmacol. Exp. Ther. 284, 858-867
 |  Abstract »  |  Full Text »

SB 202026: A Novel Muscarinic Partial Agonist with Functional Selectivity for M1 Receptors.

J. M. Loudon, S. M. Bromidge, F. Brown, M. S. G. Clark, J. P. Hatcher, J. Hawkins, G. J. Riley, G. Noy, and B. S. Orlek (1997)
J. Pharmacol. Exp. Ther. 283, 1059-1068
 |  Abstract »  |  Full Text »

Nerve Growth Factor-independent Reduction in Choline Acetyltransferase Activity in PC12 Cells Expressing Mutant Presenilin-1.

W. A. Pedersen, Q. Guo, B. K. Hartman, and M. P. Mattson (1997)
J. Biol. Chem. 272, 22397-22400
 |  Abstract »  |  Full Text »  |  PDF »

Neurotensin and Substance P Inhibit Low- and High-Voltage-Activated Ca2+ Channels in Cultured Newborn Rat Nucleus Basalis Neurons.

M. Margeta-Mitrovic, J. J. Grigg, K. Koyano, Y. Nakajima, and S. Nakajima (1997)
J Neurophysiol 78, 1341-1352
 |  Abstract »  |  Full Text »  |  PDF »

Two Restricted Sites on the Surface of the Nerve Growth Factor Molecule Independently Determine Specific TrkA Receptor Binding and Activation.

K. Kullander, D. Kaplan, and T. Ebendal (1997)
J. Biol. Chem. 272, 9300-9307
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Xanomeline, a Selective Muscarinic Receptor Agonist, on Cognitive Function and Behavioral Symptoms in Alzheimer Disease.

N. C. Bodick, W. W. Offen, A. I. Levey, N. R. Cutler, S. G. Gauthier, A. Satlin, H. E. Shannon, G. D. Tollefson, K. Rasmussen, F. P. Bymaster, et al. (1997)
Arch Neurol 54, 465-473
 |  Abstract »  |  PDF »

Neurochemical Effects of 3-[1-(Phenylmethyl)-4-Piperidinyl]-1-(2,3,4,5-Tetrahydro-1H-1-Benzazepin-8-yl)-1-Propanone Fumarate (TAK-147), a Novel Acetylcholinesterase Inhibitor, in Rats.

K. Hirai, K. Kato, T. Nakayama, H. Hayako, Y. Ishihara, G. Goto, and M. Miyamoto (1997)
J. Pharmacol. Exp. Ther. 280, 1261-1269
 |  Abstract »  |  Full Text »

Pharmacological Activity and Safety Profile of P10358, a Novel, Orally Active Acetylcholinesterase Inhibitor for Alzheimer's Disease.

C. P. Smith, G. M. Bores, W. Petko, M. Li, D. E. Selk, D. K. Rush, F. Camacho, J. T. Winslow, R. Fishkin, D. M. Cunningham, et al. (1997)
J. Pharmacol. Exp. Ther. 280, 710-720
 |  Abstract »  |  Full Text »

Nontoxic Amyloid beta Peptide1-42 Suppresses Acetylcholine Synthesis. POSSIBLE ROLE IN CHOLINERGIC DYSFUNCTION IN ALZHEIMER'S DISEASE.

M. Hoshi, A. Takashima, M. Murayama, K. Yasutake, N. Yoshida, K. Ishiguro, T. Hoshino, and K. Imahori (1997)
J. Biol. Chem. 272, 2038-2041
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Cerebral Blood Flow Correlates of Apathy in Alzheimer Disease.

A. H. Craig, J. L. Cummings, L. Fairbanks, L. Itti, B. L. Miller, J. Li, and I. Mena (1996)
Arch Neurol 53, 1116-1120
 |  Abstract »  |  PDF »

Trans-Synaptic Stimulation of Cortical Acetylcholine Release after Partial 192 IgG-Saporin-Induced Loss of Cortical Cholinergic Afferents.

J. Fadel, H. Moore, M. Sarter, and J. P. Bruno (1996)
J. Neurosci. 16, 6592-6600
 |  Abstract »  |  Full Text »  |  PDF »

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