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Science 26 February 1982:
Vol. 215. no. 4536, pp. 1119 - 1121
DOI: 10.1126/science.7063843
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Articles

Science, Vol 215, Issue 4536, 1119-1121
Copyright © 1982 by American Association for the Advancement of Science

articles

Splitting of the circadian rhythm of activity is abolished by unilateral lesions of the suprachiasmatic nuclei

GE Pickard and FW Turek

The circadian rhythm of activity in vertebrates often splits into two components after continuous exposure to constant light. This observation suggests that at least two circadian pacemakers underlie the activity rhythm. After unilateral ablation of the hypothalamic suprachiasmatic nuclei in hamsters, the splitting phenomenon was eliminated and a single rhythm of activity was established. The period of the new circadian activity rhythm different from the periods of the split rhythm and that preceding the split. These results suggest an interaction between the bilaterally paired suprachiasmatic nuclei in the generation of the circadian rhythm of activity.


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Antiphase Oscillation of the Left and Right Suprachiasmatic Nuclei.
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Quantitative analysis of the age-related fragmentation of hamster 24-h activity rhythms.
P. D. Penev, P. C. Zee, and F. W. Turek (1997)
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The Two-Oscillator Circadian System of Tree Shrews (Tupaia belangeri) and Its Response to Light and Dark Pulses.
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Cellular Analysis of Ocular Circadian Pacemaker Coupling in Bulla: Role of Efferent Impulses in Phase Shifting.
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Entrainment of Split Circadian Activity Rhythms in Hamsters.
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The opioid peptide dynorphin, circadian rhythms, and starvation.
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Regulation of circadian rhythmicity.
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