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Science 26 February 1982:
Vol. 215. no. 4536, pp. 1102 - 1104
DOI: 10.1126/science.7063842
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Articles

Science, Vol 215, Issue 4536, 1102-1104
Copyright © 1982 by American Association for the Advancement of Science

articles

Development of a monoclonal antibody against a tumor-associated antigen

WW Peng, JP Bressler, E Tiffany-Castiglioni, and J de Vellis

A monoclonal antibody-producing hybrid cell line was obtained by fusing mouse myeloma cells with spleen cells from a mouse immunized with C6 glioma cells. This antibody binds to a specific cell-surface antigen that is present on C6 rat glioma cells, transformed astrocytes and oligodendrocytes, and a human glioma cell line but is absent on a normal glial cell line, fibroblasts, and primary cultures of astrocytes and oligodendrocytes. The antigen also appears on tumor tissue of transformed oligodendrocytes but not on normal brain tissue.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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A. N. Baldwin and E. M. Shooter (1995)
J. Biol. Chem. 270, 4594-4602
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