Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 19 February 1982:
Vol. 215. no. 4535, pp. 999 - 1001
DOI: 10.1126/science.7156980
Prev | Table of Contents

Articles

Science, Vol 215, Issue 4535, 999-1001
Copyright © 1982 by American Association for the Advancement of Science

articles

Increased axonal proteolysis in myelin-deficient mutant mice

RA Nixon

Protein degradation within retinal ganglion cell axons in vitro is 50 to 110 percent faster than normal in mutant mice exhibiting deficiencies of myelin in the central nervous system. Proteolysis is increased proximally and distally within retinal ganglion cell axons of mice carrying the jumpy mutation or its allele, myelin synthesis deficiency, and is increased distally within those axons of quaking mice. The proteolytic defect is axon (neuron)-specific since the rate of protein degradation within glial cells is normal. Increased axonal proteolysis does not bear a simple relation to hypomyelination since shiverer, another mouse mutant deficient in central myelin, displayed normal rates of axonal protein degradation under the same conditions. These observations suggest an abnormal axon-glial interaction in mice with primary glial defects and raise the possibility that the functioning of histologically normal axons (neurons) may be altered in dysmyelinating diseases.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
{alpha}-Internexin Is Structurally and Functionally Associated with the Neurofilament Triplet Proteins in the Mature CNS.
A. Yuan, M. V. Rao, T. Sasaki, Y. Chen, A. Kumar, Veeranna, R. K. H. Liem, J. Eyer, A. C. Peterson, J.-P. Julien, et al. (2006)
J. Neurosci. 26, 10006-10019
   Abstract »    Full Text »    PDF »
Proteolipid Protein Gene Modulates Viability and Phenotype of Neurons.
S. E. M. Boucher, M. A. Cypher, L. R. Carlock, and R. P. Skoff (2002)
J. Neurosci. 22, 1772-1783
   Abstract »    Full Text »    PDF »
Proteolipid Protein Gene Product Can Be Secreted and Exhibit Biological Activity during Early Development.
M. Yamada, A. Ivanova, Y. Yamaguchi, M. B. Lees, and K. Ikenaka (1999)
J. Neurosci. 19, 2143-2151
   Abstract »    Full Text »    PDF »
Dynamic Organization of Endocytic Pathways in Axons of Cultured Sympathetic Neurons.
C. C. Overly and P. J. Hollenbeck (1996)
J. Neurosci. 16, 6056-6064
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)