Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 19 February 1982:
Vol. 215. no. 4535, pp. 987 - 989
DOI: 10.1126/science.6818687
Prev | Table of Contents | Next

Articles

Science, Vol 215, Issue 4535, 987-989
Copyright © 1982 by American Association for the Advancement of Science

articles

Cardiac catabolic factors: the degradation of heart valve intercellular matrix

RS Decker and JT Dingle

Cultures of porcine heart valves and aorta secrete a factor that stimulates the degradation of cartilage matrix in a fashion similar to that displayed by synovial catabolin. The heart valve factor also induces the release of chondroitin sulfate and hydroxyproline from isolated heart valve cultures. The present observations support the hypothesis that tissues producing catabolic factors (catabolins) may well be responsive to them and that these messengers may play a role in the cellular regulation of the degradation of intercellular macromolecules.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Activated Interstitial Myofibroblasts Express Catabolic Enzymes and Mediate Matrix Remodeling in Myxomatous Heart Valves.
E. Rabkin, M. Aikawa, J. R. Stone, Y. Fukumoto, P. Libby, and F. J. Schoen (2001)
Circulation 104, 2525-2532
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)